metabolic factors nafld on the natural history ofchronic hepatitis b or c in asia资料

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1、MetabolicFactors/NAFLDontheNaturalHistoryofChronicHepatitisBorCinAsiaPei-JerChenNationalTaiwanUniversity&HospitalInsulinresistanceMetabolicFactorsHBVorHCVHepaticsteatosis23820cohortmembers(11973malesand11847females),recruitedin19914155HBsAgsero-positive(2445malesand1

2、710females)19665HBsAgsero-negative(9528malesand10137females---antiHCVassayFlowchartoftheREVEALcohortHBVDNATG.Chole.HCVRNADMCross-SectionStudy:CHB/CHCversusControlintermsofMetabolicFactorsAstudyofbase-linedataintheREVEALcohortMetabolicfactors:ObesityCentralobesity:wai

3、stcircumferences>90cmformenand>80cmforwomen.BodyMassIndex:normalweightBMI<23kg/m2overweight2330kg/m2Hypercholesterolemia:totalcholesterol>240mg/dLHypertriglyceridemia:TG>150mg/dLHistoryofDMHistoryofhypertensionTable.Multi

4、variate-adjustedoddsratiosofbeingHBsAgseropositiveinrelationtoselectedmetabolicfactorsHBVInfectiondoesnotCorrelateswiththeDevelopmentofNAFLorIR(1)AuthorSettingPopulationResultsRemarksMoucari(2008)Cross-sectional500CHC,100CHBIR:5%inCHBand35%inCHCNotmatchedWang(2007)He

5、althexamination50CHBand457controlsHBVcarriersnotassociatedwithIRorFLSmallsamplesizeMohammad(2006)Casecontrol60CHCand40CHBHOMA-IRassociatedwithfibrosisinCHC,butnotinCHBSelectionbias,smallsizeTsochatzis(2007)Caseseries213eAg-veCHBHepaticsteatosislessfrequentinCHBthanin

6、CHC;associatedwithmetabolicfactorsSelectionbias,notrepresentativeCindoruk(2007)Treatmentcohort140CHBPresenceofsteatosisnotassociatedwithHBVloadSelectionbias,notrepresentativeDemir(2007)Caseseries49eAg-veCHBNAFLD:mostcommoncauseofelevatedALTinpatientswithCHBSelectionb

7、ias,smallsizeMoucarietal,Gastroenterology2008;Wangetal,JGH2007;Mohammadetal,IndianJGastroenterol2006;Tsochatzisetal,DisLiverDis2007;Linetal,WJG2007;Cindoruketal,JClinGastroenterol2007;Demiretal,AnnHepatol2007AuthorSettingPopulationResultsRemarksPersico(2009)Cohort726

8、CHC,126CHBAgeandBMIcorrelatewithsteatosisinCHBSelectionbiasYun(2009)Liverbiopsyseries86youngmaleCHBSteatosisassociatedwithTGlevelan