系统性红斑狼疮 sle课件

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1、系统性红斑狼疮(SLE)SystemicLupusErythematosusSystemicLupusErythematosusManyDifferentAuto-antibodiesMultipleSystemInvolvementSLEonsetbysexandageEtiologyandpathogenesispathologyClinicalfindingsLaboratoryfindingsDiagnosisTreatmentprognosisEtiologygeneticfactorsenvironmentalfactors

2、SexhormonalfactorsPathogenesisExcessive,abnormalproductionof“self”antibodiesandformationofIC.Autoantibodiesagainstnuclear,cytoplasmicandmembranecomponentsofmultiplecelltypesinmultipleorgans.EtiologyandpathogenesispathologyClinicalfindingsLaboratoryfindingsDiagnosisTreatm

3、entprognosisPathology光镜:1.结缔组织的纤维蛋白样变性2.基质黏液性水肿3.坏死性血管炎特征性:疣状心内膜炎苏木紫小体“洋葱皮样”病变临床应用：皮肤狼疮带试验肾活检EtiologyandpathogenesispathologyClinicalfindingsLaboratoryfindingsDiagnosisTreatmentprognosisSystemicfeaturesFeverWeakWeightlossskinandmucosa光敏感photosensitivity脱发alopecia雷诺现象Rayn

4、aud’sphenomenon口腔溃疡oralulcer皮疹rashskinandmucosaskinandmucosaskinandmucosaskinandmucosaskinandmucosaskinandmucosaMuscleandJointarthritis--Jaccoud’sarthropathyMusclepain、myositisfemoralheadnecrosisMuscleandJointRenallesionProteinuriahematuriacylindruriaNephriticsyndromeRen

5、alinsufficiencylupusnephritisClassI正常ClassII系膜增殖性mesangialClassIII局灶增殖性focalproliferativeClassIV弥漫增殖性diffuseproliferativeClassV膜性membranousClassVI肾小球硬化性glomerulosclerosisNervoussystemclinicalmanifestation:-headache、vomiting-psychogenia-epilepsy-convulsion、consciousdistur

6、bance-comapathology-vasculitiscerebrospinalfluid-nospecial(intracranialpressure↑protein↑cellpopulation↑glucose↓)IdentifywithothercentralnervoussystemdiseaseHematologysystemleukopeniathrombocytopeniaanemias:hemolyticanemiasanemiasofchronicdiseaselymphadenectasissplenectas

7、isRespiratorysystempleurisyPleuraleffusionPulmonaryinterstitialfibrosisLupuspneumoniaPulmonaryhypertensionRespiratoryfailurelungCirculatorysystemheart-pericarditis-myocarditis-endocarditisLibman-Sackendocarditis-cardiacarrhythmias-cardiacfailurevessel-vasculitisDigestive

8、systemClinicalfeatures-anepithymia-nauseaandvomiting-abdominalpain、diarrhea-peritonealeffusion-acuteabd