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时间:2020-05-07
《介入治疗联合干细胞移植治疗肝硬化临床分析-论文.pdf》由会员上传分享,免费在线阅读,更多相关内容在应用文档-天天文库。
1、第24卷第10期航空航天医学杂志2013年l0月1153·论著·介入治疗联合干细胞移植治疗肝硬化临床分析杨彦林刘艳茹王丽华付广印韩东亮李华吴国良杨占辉王树平[摘要]目的:探讨和评价介入治疗联合干细胞移植治疗失代偿期肝硬化的近期疗效及其安全性。方法:3O例失代偿期肝硬化患者,随机分为3组,每组各10例。A组仅行药物治疗,B组行TIPS治疗,C组行TIPs联合脐带血干细胞移植治疗。术前1周、术后1月及术后3月观察3组患者丙氨酸氨基转移酶(ALT)、白蛋白(ALB)、总胆红素(TBIL)水平变化及并发症情况。结果:手术及干细胞移植顺利,3组患者术前ALT、ALB、TB均无明显差
2、异;A组患者药物治疗前后肝功能无特殊变化;B组患者术后1月、3月时ALT(P<0.01)及术后1月时TB(P3、[关键词]经颈内静脉肝内门体分流术;脐带血干细胞;肝硬化失代偿期;干细胞移植;介入放射学中图分类号:R815文献标识码:A文章编号:2095—1434.2013.10.001TheEficacyofInterventionalTherapyTogetherwithStemCellTransplanta-tioninTreatmentofDecompensatedCirrhosisYANGYanlin,LIUYanru,WANGLihua,eta1.(DepartmentofInterventionalTherapy,Hengshui053000,China)Abstrac4、tObjective:Toevaluateandassesstheshoa—termefficacyofinterventionaltherapytogetherwithstemcelltransplantationinthetreatmentofpatientswithdecompensatedcirrhosis.Methods:30patientsweredividedintothreegroupsrandomly.GroupAonlyuseddrugs,groupBadoptedTIPs,groupCadoptedTIPSandumbiliccordbloodste5、mcelltransplantation.Alanineaminotransferase(AIJT),albumin(ALB)andtotalbilirubin(TIBL)wereobservedatpre—operation.1monthand3monthsaftertransplantationweremeasuredandanMyzedineachgroup.Theadversereactionwasalsoobserved.Results:TIPSandtranslationwascarriedoutsuccessfully.Therehadnosignifica6、ntdifferentofALTALBandTBbetween3groupspre—operation.ItshowednosignificantchangeingroupA.YetingroupBthelevelofALTwasincreasedat1and3monthsafterTIPS(P<0.O1),andsodidTBat1monthafteroperation(P<0.05).ALTdecreasedsignificantlyat3monthsaftertransplantation(P<0.05)ingroupC,andthelevelofALBincrea7、sedsignificant—lyatthesametimealthoughitstillunderthelowerlimit(35g/L).ThelevelofALTandTBwashigheringroupBat1monthafterTIPScomparedwithAandC(P<0.05).WhileingroupC,ALTwaslowerat3monthsaftertransplantation(P<0.05),butALBwasmuchhighercomparedwithA作者单位:1河北省衡水市哈励逊国际和平医院介
3、[关键词]经颈内静脉肝内门体分流术;脐带血干细胞;肝硬化失代偿期;干细胞移植;介入放射学中图分类号:R815文献标识码:A文章编号:2095—1434.2013.10.001TheEficacyofInterventionalTherapyTogetherwithStemCellTransplanta-tioninTreatmentofDecompensatedCirrhosisYANGYanlin,LIUYanru,WANGLihua,eta1.(DepartmentofInterventionalTherapy,Hengshui053000,China)Abstrac
4、tObjective:Toevaluateandassesstheshoa—termefficacyofinterventionaltherapytogetherwithstemcelltransplantationinthetreatmentofpatientswithdecompensatedcirrhosis.Methods:30patientsweredividedintothreegroupsrandomly.GroupAonlyuseddrugs,groupBadoptedTIPs,groupCadoptedTIPSandumbiliccordbloodste
5、mcelltransplantation.Alanineaminotransferase(AIJT),albumin(ALB)andtotalbilirubin(TIBL)wereobservedatpre—operation.1monthand3monthsaftertransplantationweremeasuredandanMyzedineachgroup.Theadversereactionwasalsoobserved.Results:TIPSandtranslationwascarriedoutsuccessfully.Therehadnosignifica
6、ntdifferentofALTALBandTBbetween3groupspre—operation.ItshowednosignificantchangeingroupA.YetingroupBthelevelofALTwasincreasedat1and3monthsafterTIPS(P<0.O1),andsodidTBat1monthafteroperation(P<0.05).ALTdecreasedsignificantlyat3monthsaftertransplantation(P<0.05)ingroupC,andthelevelofALBincrea
7、sedsignificant—lyatthesametimealthoughitstillunderthelowerlimit(35g/L).ThelevelofALTandTBwashigheringroupBat1monthafterTIPScomparedwithAandC(P<0.05).WhileingroupC,ALTwaslowerat3monthsaftertransplantation(P<0.05),butALBwasmuchhighercomparedwithA作者单位:1河北省衡水市哈励逊国际和平医院介
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