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时间:2020-04-12
《《茶多酚对大鼠骨折早期愈合及TNF-α表达影响的实验研究》.pdf》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、国眶
2、匿—国同2015年6月第13卷第17期·论著·5茶多酚对大鼠骨折早期愈合及TNF-表达影响的实验研究严斌(深圳市坪山新区人民医院外科,广东深圳518118)【摘要】目的探讨茶多酚对大鼠骨折早期愈合及TNF一0【表达的影响,为茶多酚促进骨折愈合提供理论参考。方法选取90只大鼠进行茶多酚追模,随机分为两组,模型组45例只给予造模,药物组45例在造模后给予茶多酚干预,另外选取45只大鼠仅给予生理盐水干预作为正常组,比较三组的骨折愈合情况及TNF—d的表达情况。结果模型组与药物组在整个实验过程中,一c【结果均显著高于正常组,有统计学差异(P<0.05)。TNF—o【检测结果显示,药
3、物组合模型组在第14天和第21天差异具有显著性,尤其是第21天,差异具有非常显著性(尸l4、号:1671-8194(2015)17-0005-02ExpedmentMStudyOilEarlyHealingandTNF—MphaExpressionandEfectsofTeaPolyphenolsOilRatFracture】二4Ⅳ(DepartmentofSurgery,ShenzhenPingshanNewDistrictPeople'sHospital,Shenzhen518118,China)【Abstract]ObjectiveToinvestigatetheefectofearlyhealingandTNF一Ⅱexpressionofteapolypheno5、lsonratfracture,teapolyphenolsandprovideatheoreticalreferenceforpromotingfracturehealing.MethodsAtotalof90ratsweremademodelofteapolyphenols,wererandomlydividedintotwogroups,themodelgroup45patientsweretreatedonlybymodeling,45casesgaveherteapolyphenolsinterventioninthemodelgroup,theother45ratsw6、ereselectedasnormalsalineinterventiongroup,theexpressionofthreegroupsoffracturehealingandTNF—alpha.ResultsInthemodelgroupanddruggroupduringthewholeexperiment,theresultsofTNF—alphaweresignificantlyhigherthanthoseinnormalgroup,therewasstatisticallysignificantdiference(P7、owedthatthemodelgroup,drugcombinationhadsignificantdiferencesin14daysand21days,especiallythe21days,thediferencewassignificant(P8、lphaindruggroupwaslowerthanthemodelgroup,therewasstatisticalsignificance(P<0.05).Thethirdday,thecallusthicknessdruggroupandmodelgroupandmaturityhadnosignificantdiference,thestartoftheseventhday,thecallusthicknessofdruggroupwashigherthanthatof
4、号:1671-8194(2015)17-0005-02ExpedmentMStudyOilEarlyHealingandTNF—MphaExpressionandEfectsofTeaPolyphenolsOilRatFracture】二4Ⅳ(DepartmentofSurgery,ShenzhenPingshanNewDistrictPeople'sHospital,Shenzhen518118,China)【Abstract]ObjectiveToinvestigatetheefectofearlyhealingandTNF一Ⅱexpressionofteapolypheno
5、lsonratfracture,teapolyphenolsandprovideatheoreticalreferenceforpromotingfracturehealing.MethodsAtotalof90ratsweremademodelofteapolyphenols,wererandomlydividedintotwogroups,themodelgroup45patientsweretreatedonlybymodeling,45casesgaveherteapolyphenolsinterventioninthemodelgroup,theother45ratsw
6、ereselectedasnormalsalineinterventiongroup,theexpressionofthreegroupsoffracturehealingandTNF—alpha.ResultsInthemodelgroupanddruggroupduringthewholeexperiment,theresultsofTNF—alphaweresignificantlyhigherthanthoseinnormalgroup,therewasstatisticallysignificantdiference(P7、owedthatthemodelgroup,drugcombinationhadsignificantdiferencesin14daysand21days,especiallythe21days,thediferencewassignificant(P8、lphaindruggroupwaslowerthanthemodelgroup,therewasstatisticalsignificance(P<0.05).Thethirdday,thecallusthicknessdruggroupandmodelgroupandmaturityhadnosignificantdiference,thestartoftheseventhday,thecallusthicknessofdruggroupwashigherthanthatof
7、owedthatthemodelgroup,drugcombinationhadsignificantdiferencesin14daysand21days,especiallythe21days,thediferencewassignificant(P8、lphaindruggroupwaslowerthanthemodelgroup,therewasstatisticalsignificance(P<0.05).Thethirdday,thecallusthicknessdruggroupandmodelgroupandmaturityhadnosignificantdiference,thestartoftheseventhday,thecallusthicknessofdruggroupwashigherthanthatof
8、lphaindruggroupwaslowerthanthemodelgroup,therewasstatisticalsignificance(P<0.05).Thethirdday,thecallusthicknessdruggroupandmodelgroupandmaturityhadnosignificantdiference,thestartoftheseventhday,thecallusthicknessofdruggroupwashigherthanthatof
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