氯诺昔康固体分散剂的制备与表征.docx

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1、内蒙古医科大学毕业论文题目氯诺昔康固体分散体的制备与表征学生姓名张佳玮姚丽芳薛猛学号201009275120100927712010092726院系药学院专业药学指导教师刘涛二Ｏ一四年六月九日氯诺昔康固体分散体的制备和表征内蒙古医科大学2010级药学专业，呼和浩特010059张佳玮姚丽芳薛猛摘要:[目的]:制备氯诺昔康不同载体固体分散体。[方法]:选择聚乙烯吡咯烷酮K30(PVP)和泊洛沙姆这两种载体,用熔融法和溶剂法制备了氯诺昔康固体分散体,对其进行红外光谱分析和差热图谱分析以鉴别药物在载体中的存在状态。[结果]:熔融法和溶剂法可用于氯诺昔康固体分散体的制备,氯诺昔康可充分分散在载体中并形成

2、低共熔物。[结论]:能否形成固体分散体与载体性质有关，同时载体与药物的比例也有影响，一般比例越大越容易形成固体分散体。关键词:氯诺昔康；固体分散体；红外光谱图；差热分析。Representationandpreparationofsoliddispersionoflornoxicam(DepartmentofPharmacy,AffiliatedHospital,InnerMongoliaMedicaluniversity,Hohhot010050China)Abstract:[objective]:preparationoflornoxicam,differentcarriersoliddi

3、spersions.[methods]:selectpolyvinylpyrrolidoneK30(PVP)andPoloxamerthistwokindsofthecarrier,byusingthemeltingmethodandsolventlornoxicam,soliddispersionwasprepared,theinfraredspectrumanalysistoidentifydrugcarrierinthestateofbeing.[results]:meltingmethodandsolventmethodcanbeusedforlornoxicamthepreparat

4、ionofsoliddispersions,lornoxicam,canbefullydispersedincarrierandformeutectic..[conclusion]:canformsoliddispersionrelatedtothenatureofthecarrier,alsohaseffectontheratioofthecarrierwithdrugatthesametime,generalproportionbiggeriseasytoformsoliddispersions.Keywords:lornoxicam;Soliddispersion;Infraredspe

5、ctrogram;Differentialthermalanalysis.目录1摘要.......................................................................................12前言.......................................................................................53仪器与材料.........................................................................

6、....64实验方法64.1氯诺昔康的提取64.1.1提取64.1.2重结晶：74.1.3滤渣提取..........................................................................74.2氯诺昔康固体分散体的制备74.2.1固体分散体Ⅰ.....................................................74.2.2固体分散体Ⅱ74.3氯诺昔康固体分散体的表征......................................75结果与讨论.......................

7、....................................................84附图.......................................................................................9参考文献………………………………………………………………16前言氯诺昔康[1](Lornoxicam)是一种新的