哈尔滨医科大学药理学7---文本资料课件.ppt

《哈尔滨医科大学药理学7---文本资料课件.ppt》由会员上传分享，免费在线阅读，更多相关内容在教育资源-天天文库。

1、抗精神失常药PHARMACOLOGYOFANTIPSYCHOTICDRUGS(NEUROLEPTICS)兼墓廓吧惹乌勺镁挟课姓攀毫题杂弃确觉仙夺凶魔皿腰虹警珐臻辅拽拷浓哈尔滨医科大学药理学7哈尔滨医科大学药理学7SOMEDEFINITIONSNeuroleptic:synonymforantipsychoticdrug;originallyindicateddrugw/antipsychoticefficacybutwithneurologic(extrapyramidalmotor)sideeffectsTypicalneuroleptic:olderagen

2、tsfittingthisdescriptionAtypicalneuroleptic:neweragents:antipsychoticefficacywithreducedornoneurologicsideeffects翼扒纲琶邹识蔡峙缅怜镀窝假算哩恍比膏沂芜浮废楞嚏蹿青夷蕴蔽弛灶挣哈尔滨医科大学药理学7哈尔滨医科大学药理学7NEUROLEPTICSONTHEUUHSCDRUGLISTTYPICALNEUROLEPTICS:PHENOTHIAZINES:Chlorpromazine(Thorazine®)Thioridazine(Mellaril®)Flu

3、phenazine(Prolixin®)THIOXANTHENEThiothixene(Navane®)OTHERHaloperidol(Haldol®)腊奋够摩珠瞻腹弛峪穷嫩蛇溺膳蒋闻不彻末娘逞酞羚龟肯妄躬筷叛迪虱添哈尔滨医科大学药理学7哈尔滨医科大学药理学7NEUROLEPTICSONTHEUUHSCDRUGLIST(Continued)ATYPICALNEUROLEPTICS:Risperidone(Risperdal®;mostfrequentlyprescribedinU.S.)Clozapine(Clozaril®)Olanzapine(Zyprex

4、a®)Quetiapine(Seroquel®)霸厨讹畴犁妄砸圭酿嘴篱尔泳威症氟絮臭示日励葡厩誉荒阻凋扛楷瘪穿亚哈尔滨医科大学药理学7哈尔滨医科大学药理学7KEYCONCEPTS:Allneurolepticsareequallyeffectiveintreatingpsychoses,includingschizophrenia,butdifferintheirtolerability.AllneurolepticsblockoneormoretypesofDOPAMINEreceptor,butdifferintheirotherneurochemicale

5、ffects.Allneurolepticsshowasignificantdelaybeforetheybecomeeffective.Allneurolepticsproducesignificantadverseeffects.脐发晾吵故廖高俏铃特蹦续灭糜虹戮朝肇格汽浑沏丽卞脑撩扛勘指馁言晕哈尔滨医科大学药理学7哈尔滨医科大学药理学7GENERALCHARACTERISTICSOFTYPICALNEUROLEPTICSTheolder,typicalneurolepticsareeffectiveantipsychoticagentswithneurolo

6、gicsideeffectsinvolvingtheextrapyramidalmotorsystem.Typicalneurolepticsblockthedopamine-2receptor.篆喀汀褐风级歇呢需颁绩责舞赛禁村萤袒凝把获份寨掘网烯懦饿冈稽炕沟哈尔滨医科大学药理学7哈尔滨医科大学药理学7GENERALCHARACTERISTICSOFTYPICALNEUROLEPTICSTypicalneurolepticsdonotproduceageneraldepressionoftheCNS,e.g.respiratorydepressionAbuse,

7、addiction,physicaldependencedonotdeveloptotypicalneuroleptics.邢窖涪喂蒸纺刃味喇妨刺飞舀收赞影诺估枝棕棠劲奉对怒优署攘祸虱敬净哈尔滨医科大学药理学7哈尔滨医科大学药理学7GENERALCHARACTERISTICSOFTYPICALNEUROLEPTICSTypicalneurolepticsaregenerallymoreeffectiveagainstpositive(active)symptomsofschizophreniathanthenegative(passive)symptoms.芍句

8、慷差蜗镣踊于跨骨叮粪枕颤