电针对血管性痴呆模型大鼠学习记忆能力的影响（英文）.pdf

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1、J．Acupunct．Tuina．Sci．2012，10(2)：67—71DOI：10．1007／s11726—0l2—0573—1BasicStudyEffectofElectr0acupunctureonLearningandMemoryinRatswithscularDementia电针对血管性痴呆模型大鼠学习记忆能力的影响MengPei—yan(孟培燕)，SunGuo-jie(孙国杰)，MaoJuan-juan(毛娟娟)，SuFu—rong(苏芙蓉)，ZhouCi—li(周次利)Hube

2、iCollegeofTraditionalChineseMedicine，Wuhan430061，P．R．China【摘要】目的：观察电针对血管性痴呆大鼠学习记忆能力的影响。方法：将72只SD大鼠随机分为4组，即正常组、假手术组、模型组和电针预处理组。采用改良线栓法制备血管性痴呆大鼠模型，观察电针对血管性痴呆大鼠Morris水迷宫的学习记忆能力。结果：模型组大鼠在水迷宫实验中的平均逃避潜伏期延长，与假手术组比较差异具有统计学意义(尸<0．011。经电针预处理后，大鼠平均逃避潜伏期及定位航行试验成

3、绩与模型组大鼠相比，差异有统计学意义(P

4、dedinto4groups，anormalgroup，ashamoperationgroup，amodelgroupandanelectroacupuncture(EA)pretreatmentgroup．Modifiedintraluminalembolismmethodwithnylonthreadwasappliedtomakeratmodelofvasculardementia，andtheabilityoflearningandmemorywasobservedinMorriswat

5、ermaze．Results：Theaveragetimeofescapeandlatencyintheratsofmodelgroupinthewatermazetestwasprolonged，withsignificantdiferencecomparedwiththatintheshamgroup(Jp<0．011．TheaveragetimeofeSCrdDeandlatencyandnavigationtestresultsofratspretreatedbyEAhadstatist

6、icallysignificantdiferencecomparedwiththoseofthemodelgroupf尸<0．01)．Conclusion：EApretreatmentcansignificantlyimprovetheabilityoflearningandmemoryoftheratswithvasculardementia．【KeyWords】Dementia，Vascular；Electroacupuncture：AcupunctureTherapy；Memory；Maz

7、eLearning；RatsVasculardementiafVD)isasyndromeofacquiredlMaterialsandMethodsintellectualimpairmentofbrainfunctioncausedbyavarietyofcerebrovasculardiseases．Itisoneofthe1．1AnimalsandgroupingmaintypesofseniledementiamainlywithSeventy．twofemalehealthySDra

8、tsof200—250gimpairmentofmemoryandcognition．VDisinweightrl0weeks)wererandomlydividedinto4reversiblewithactivepreventionandearlytreatment．groups，anormalgroup，ashamoperationgroup，aInordertofurtherexplorethecentralmechanismofmodelgroupandanelectroacupunc