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1、两种测量方法定量测量结果的一致性评价∗李镒冲李晓松四川大学华西公共卫生学院卫生统计学教研室[摘要]目的比较两种测量方法定量测量结果的一致性评价方法的优劣。方法应用配对t检验、简单相关分析、组内相关系数以及Bland-Altman法对某一致性较好的实例以及其衍生出的系统误差较大、随机误差较大以及测量范围局限三种情况进行一致性评价。结果对实例一致性评价中，简单相关分析、组内相关系数与Bland-Altman法显示一致性较好，配对t检验显示一致性较差；系统误差较大情况下，简单相关分析显示较好一致性，而配对t检验、组内相关
2、系数与Bland-Altman法显示一致性较差；随机误差较大情况下，配对t检验显示一致性较好，而简单相关分析、组内相关系数与Bland-Altman法显示一致性较差；在测量范围局限而随机误差和系统误差均小情况下，配对t检验与Bland-Altman法显示较好一致性，而简单相关分析与组内相关系数显示一致性较差。结论配对t检验与简单相关分析作为一致性评价方法有明显缺陷，而组内相关系数与Bland-Altman法虽有一定局限但可作为一致性评价的优选方法。[关键词]一致性配对t检验简单相关系数组内相关系数Bland-Alt
3、man法AgreementassessmentofdataobtainedfromtworatersbasedoncontinuousmeasurementsLiYichong,LiXiaosong,HuaxiSchoolofPublicHealth,SichuanUniversity,610041ObjectiveToevaluatetheAgreementofquantitativemeasurementsoftworaters.MethodsExpoundingtheadvantagesanddisadvan
4、tagesofpairedttest,simplecorrelationcoefficient,intra-classcorrelationcoefficients(ICC)andBland-Altmanmethod.Eachmethodwasusedtoevaluatetheagreementofatruedataandthreehypotheticalsituationsdevelopedfromthetrueone.ResultsInthesituationoftruedatademonstratinggoo
5、dagreement,correlationcoefficient,theICCandBland-Altmanmethodindicatedgoodagreement,butpairedttestsuggestedthedatawasnotreliable.Inthesituationdemonstratingsystematicbias,theICC,pairedttestandBland-Altmanmethodsuggestedthedatawerenotreliable,whereasthePearsonc
6、orrelationsuggestedhighreliabilitydespitethesystematicdiscrepancy.Inthesituationrepresentingsubstantialrandomerrorwherelowagreementwasexpected,theICC,correlationcoefficientandBland-Altmanmethodaccuratelyillustratedthis.Thettestsuggestedthedatawerereliable.Inth
7、esituationdemonstratinglowrangeofmeasurementswherebothbiasanderrorweresmall,pairedttestandBland-Altmanmethodsuggestedgoodagreement,butICCandcorrelationcoefficientfailedtodemonstratethat.ConclusionBothpairedttestandsimplecorrelationcoefficienthaddefectsinassess
8、ingagreement,andintra-classcorrelationcoefficientsandtheBland-Altmanmethodwerethepreferabletechniquestomeasureagreementalthoughtherearesomelimitationsassociatedwiththeuseofthesetec
