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《补充双歧杆菌可促进烫伤大鼠肠道sIgA合成与分泌.pdf》由会员上传分享，免费在线阅读，更多相关内容在行业资料-天天文库。
1、neetnaeooce232IfIflmmRpVl3N4D2002补充双歧杆菌可促进烫伤大鼠肠道slgA合成与分泌l1。。。37北京解放军第304医院全军烧伤研究所基础部王忠堂姚咏明肖光夏曹卫红盛志勇、:S。:ar【摘要】目的探讨严重烫伤后补充双歧杆菌与肠道lgA合成分泌的关系方法Wist大鼠70只随机、。,n、,、,n分为烫伤对照组(BC一30)烫伤治疗组(BT~30)假伤组(NC一10)BT组伤后灌胃双歧杆菌悬液(5.。、、gc,,、xlofu/ml)1sml2/d检测大鼠细菌及内毒素移位膜菌群中双歧杆菌量肠粘液IgA浓度及肠道浆细胞。.:,,slgA表达情况等结果
2、(1)伤后3dBC组与BT组细菌移位率分别为42%和16%(尸~。。。4)伤后5d分别.。为30%和8%(尸一。02)(2)伤后大鼠;灌胃双歧杆菌悬液后肠道双盲肠膜菌群中双歧杆菌减少约10一60倍。s,。(3)BC组肠粘液lgA平均减少约30%伤后3d达最低;BT组3d伤后基本恢复正常伤后歧杆菌明显增多s,S,。回肠粘膜下固有层浆细胞lgA表达减弱补充双歧杆菌后址A表达显著增强5d接近NC组(4)膜菌群中双。S:s,歧杆菌量与肠粘液坛A浓度呈显著正相关结论严重烫伤后肠道lgA产生明显受抑制其改变与膜菌群中双,S。歧杆菌减少有关补充外源性双歧杆菌可促进肠道lgA合成与分泌
3、关键词烧伤细菌移位分泌型IgA粘膜免疫BifidobaeterialsuPPlementenhaneestheexPressionandexcretionofintestinalslgAinseve代lyburnedrats.anonan,aoonn,aouanxa,eaneaeareourosue,os-gZhgtgYYgmigXiGgitlCliilDptmntfBnlntitt304thHWa,enpitlBijig100037srcecv:onvesaeeoenaeeeooaeerasueenonnesnaueosa-AbtatObjtieTitigtthptt
4、ilfftfbifidbtilpplmtittilmlim.unassoeaesevereurnso:starrasereranovenourneonrorou,刀mityitdwithbMethdsWitwdmlydiidditbtlgp(BC.,reaenru,n,nsa一urnrou,nasnruereeoae-~30)ttmtgop(BT=30)adhmbgP(NC=10)RtiBTgopwfdbifidb..erarearaon9。uaeroaoSuraeeareau一enessurns,,eeaastilppti(5丫10f/ml)ft30%ttlbdyff
5、llthikb2smltwidilyRt...anereeorasane,,eeaaesereaennosurnas,,aneinBCdNCwfdnmlli1srnltwidilySmplwtkoptbdyl3d5Th.neeneeosanareosesevesnueusosanesneereeasureeos-iidfwithtddmthdThlgAllimfmllittiwmdbyRIAThPi.vesexressonnaninaroraaseeeeunosoeeeasannus:eneeneetilgApiilipPiwdttdbyimmhithmiltiigRe
6、slt(l)Thiid.oaeeraransoeaonereannrouanonsurna,anfbtiltltiw42%d16%iBegpdBTpotbdy3(P=0004)30%ds%..ona,reseeveasaenooxnevesereareernanrousandys(P=0002)ptilyPlmdtillwmkdlyhighiBCdBTgpthnirouaeearsaeosurn,eereasasneaneereasenrouearerouNCgptthlytgptbwhilthwigifitdiBTgPompdwithBCgp..onpostburnd
7、ayl(P=00412)(2)Thebifidobaeteriaeountsineeeummueosawereredueedby10一to60一foldaereraur,eereasararaenereasenoaeeraeounsnanaseoaee-ftthmlinjywhilthwemkbliibifidbtitiimlfdwithbifidbt.raesevesnnesnaueuseresneaneereasenrou,uereurneonorai(3)ThlgAlliittilmwigifitlyddigpBCbtthytdtm
