Wernicke脑病的常规MRI、DWI及临床表现特点.pdf

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1、神经影像学NEUROLOGfCALIMAGING209Wernicke脑病的常规MRI、DWI及临床表现特点朱晓慧金中高潘交海李强李盛陈爽【摘要】目的：探讨Wernicke脑病(WE)的常规MRI、DWI及临床表现特点。方法：回顾性分析6例经临床证实的WE患者的MRI、DWI及临床表现。结果：6NWE患者，病变多数呈对称性，累及双侧丘脑内侧及第三脑室周围5例；乳头体、四叠体、中脑导水管周围3例；脑桥被盖1例；累及双侧大脑脚1例；2例累及大脑皮质区，主要累及灰质为主，信号特点与位于丘脑内侧、第三脑室周围、中脑导水管周围乳头体、四叠体等处病灶一致。病变区T1wI表现

2、为等或稍长T1信号，T2WI表现为稍长或长T2信号，边缘均模糊不清，信号欠均匀；FLAIR呈高信号；DWI呈明显高信号4例，呈稍高信号1例，呈稍低信号1例；ADC图呈低信号4例，呈稍高信号IN，1例DWI呈稍低信号病例IADC图为高信号。结论：WE具有典型的MRI表现，DWI显示病变更加敏感，对于该病早期诊断及预后评估具有重要价值。【关键词】Wernicke脑病；磁共振成像；弥散加权成像中图分类号：R445．2文献标志码：A文章编号：10065741(20141)．03—0209．04RoutineMRI，DWIandCHnicalManifestationso

3、fWernirke’SEncephal0pathyZHUXiao—hui，JINZhong,一gaD。，PANJiao—hal。，LIQiang，LISheng，CHENGShuang4【Abstract】Purpose：ToexploretheimagecharactersandclinicalfeaturesofWernicke’Sencephalopathy(WE)onroutineMRIandDWI．Methods：RoutineMRIandDWIcharactersandclinicalsymptomsof6patientswithWEwereanal

4、yzedretrospectively．Results：Inallthe6patients，mostlesionsdisplayedsymmetricaldistribution．Fivecaseswerefoundwithlesionsinbilateralmedialthalamusandsurroundingventriculustertius．Threecaseswerewithlesionssurroundedcorpusalbicans，corporaquadrigeminaandperiaqueductalofmidbrain，1casewithl

5、esioninpontinetegmentum，1caseincerebralpeduncle，2casesincortexofbrain．Theselesionsweremainlylocatedingreymatter．TheMRIsignalfeaturesofthemweresimilar．Thelesionswereiso-orhypo·-intensityonT1WIandhyper-intensityorslighthyper-intensityonT2W1withobscureboundaryandunevensigna1．OnFLAIR，the

6、lesionsdemonstratedhperointensity．OnDWI，4casesdi~ayedevidenthyper-intensity,1casedisplayedhyper-intensityand1case'po·intensity．OnADC，4casedisplayedhypo-intensityand1casedemonstratedslighthyper-intensitysigna1．Oneeasedemonstratedhy'po—intensityonDWIbuthyper-intensityonADCimage．Conclus

7、ion：WEhascharacteristicfeaturesonMRI，especiallyonDWI，MRIhasimportantvalueforearlydiagnosisandprognosisevaluationoftheWE．【Keywords】Wernicke’Sencephalopathy；MRI,DWI中国医学计算机成像杂志，2014，20：209．212ChinComputMedImag．2014，20：209-212作者单位：1浙江省宁波市鄞州区人民医院放射科1DepartmentofRadiology,YinzhouPeople'SHo

8、spital2浙江省宁波