蚕蛹油对高脂高糖诱导大鼠脂肪性肝炎的治疗作用研究.pdf

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1、86中药药理与临床2012；28(1)9品立勋，王力伟，李唐棣，等．姜黄素包合物对实验性糖尿病商脂m量的影n向．微循环学杂志，2007；17(1)：12～14疵大鼠血糖和呶脂水平的影响．中国煤炭工业医学杂志，2011；14(1)：12陈美娟，喻斌，江亚兵，等．桔梗水提醇沉一I：清部分对链脲菌索致特95～96尿病大鼠糖耐量影响的研究．中药药理与临床．2010；26(1)：52—55lO徐锦龙，王一奇，徐佳丽，等玮叶提取物对高Jn【糖大鼠血糖及肝糖l3王元松，李永星．2型糖尿病胰岛索抵抗的中医研究近况．新中原含的影响．中华中医药学刊，2010；28(2)：413-415医，2002

2、；34(11)：73—7511邵丰，欧阳静萍，毛先晴．黄芪多糖对遗传性糖尿病小鼠肝糖原含EfectsofHedysaripolysacchcride-3onmetabolismofglucoseandlipidandpathologicalchangesofpancreatict~sueinexperimentaltype-2diabeticratsLiXiaodong一，FengDemei’ZhaoLianggong4FengShilan，，(SchoolofPharmacy，LanzhouUniversity，Lanzhou730000；GansuAcademyofTCM，

3、Lanzhou730050；TheSecondPeoplegHospitalofGansuProvince．Lanzhou730000；TheSecondClinicalMedicalSchoolofLanzhouUniversity，Lanzhou730000)Objective：Tostudyefectsofhedysafipolysaecheride一3(HPS-3)onmetabolismofglucoseandlipidandpathologicalchangesofpan—creatietissueonexperimentaltype-2diabeticrats．M

4、ethods：Toestablishanexperimentaltype-2diabeticratsmodel，theratswereselectedandseparatedintonormalcontrol，modelgroup，type一2diabeticmodelgroup，HPS-3(50、100、200mg／kg‘d)diferentdosegroupandmet-formin(200ms／kg·d)treatedgroup，randomlyaccordingtoweight．Ratsofallgroupswereadministeredbyintragastrica

5、dministration．Afterrespectivelyadministeredfor5weeks，thecontentsofglucose，theglucosetolerance，lipids(total—cholesterols，triglyeefides，high—densitylipo—proteincholesterol，low-densitylipoproteincholestero1)；livergotfromtheleaveswasusedtomeasul~glycogenbyanthrone—sulfuricacidmethod；pathological

6、changesofpancreatictissuetakenfromtheratswasstainedandobserved．Results：Comparedwiththemodelgroup，HPS一3ofthethreetreatedgroups，especiallythehighdosegroup(200mg／kg·d)couldsignificantlyreducefastingbloodglucoseinexperi—mentaltype一2diabeticratsandglucosein2hafteroralglucoseintolerancetest，whichi

7、ndicatedthattheimpairedglucosetoleranceinratswasimproved．Besidesthat，HPS一3canre~atedyslipidemiainexperimentaltype-2diabeticrats，inhibittotal—cholesterol，triglyeeridesandlow—densitylipoproteincholesterolrisingandhish—densitylipoproteincholesteroldec