干细胞：治疗勃起功能障碍的新玩家.pdf

《干细胞：治疗勃起功能障碍的新玩家.pdf》由会员上传分享，免费在线阅读，更多相关内容在行业资料-天天文库。

1、AsianJournalofAndrology(2012)14，145-155◎2012AJA．SIMM＆SJTU．Alrightsreserved1008-682)(／12$32．00WWWnature．com／ajaREVIEWStemcells：novelplayersinthetreatmentoferectiledysfunctionHaiyangZhang，Maarten．Albersen，XunboJinandGuitingLinStemcellsaredefinedbytheircapacityforbothself-renewaIanddirecteddifere

2、ntiation；thus。theyrepresentgreatpromiseforregenerativemedicine．Historically。stemcellshavebeencategorizedaseitherembryonicstemcells(ESCs)oradultstemcells(ASCs)．1twaspreviouslybelievedthatonlyESCsholdtheabilitytodifferentiateintoanycelItype．whereasASCshavethecapacitytogiveriseonlytocellsofagiven

3、germIayer．Morerecently。however。numerousstudiesdemonstratedtheabilityofASCstodiferentiateintocelItypesbeyondtheirtissueorigin．TheaimofthisreviewwastosummarizecontemporaryevidenceregardingstemcelIavailability，dIfferentiati0n。andmorespecifically，thepotentialofthesecellsinthediagnosisandtreatmento

4、ferectiledysfunction(ED)inbothanimaImodelsandhumanresearch．WeperformedasearchonPubMedforarticlesrelatedtodefinition．IocalisationandcirculationofstemcellsaswelIastheapplicationofstemcellsinbothdiagnosisandtreatmentofED．StrongevidencesupportstheconceptthatstemcelItherapyispotentiallythenextthera

5、peuticapproachforED．T0date．alargespectrumofstemcells，includingbonemarrowmesenchymalstemcells．adiposetissue-derivedstemcellsandmuscle-derivedstemcells．havebeeninvestigatedforneura1．vascular．endotheliaIorsmoothmuscleregenerationinanimaImodelsforED．1naddition。severaIsubtypesofASCsareIocalizedinth

6、epenis．andcirculatingendogenousstemcellscanbeemployedtopredicttheoutcomeofEDandED-relatedcardiOvascuIardiseases．AsianJournalofAndroloEy(2012)14．145-155；doi：1O．1038／aja．2011．79；publishedonJjne17October2011Keywords：adiposetissue—derivedstemcelIs；bonemarrowstemcelIs；erectiledysfunction；mesenchyma

7、lstemcelIs；stemcelIsINTR0DUCTIONHarvestingESCsrequiresthedestructionofhumanembryosandhasraisedsignificantethicalandpoliticalconcerns．ThesebarriersStemcellsarebydefinitioncapableofself-renewal，meaningthattheyhavepromptedthesearchforalter