磺胺嘧啶银达克罗宁复层膜治疗浅Ⅱ度烫伤的药效学考察.pdf

《磺胺嘧啶银达克罗宁复层膜治疗浅Ⅱ度烫伤的药效学考察.pdf》由会员上传分享，免费在线阅读，更多相关内容在行业资料-天天文库。

1、磺胺嘧啶银达克罗宁复层膜治疗浅Ⅱ度烫伤的药效学考察黄敏燕，陈霞，林苗，朱倩(南通市第一人民医院，江苏南通226001)摘要：目的考察磺胺嘧啶银达克罗宁复层膜对大鼠浅Ⅱ度烫伤的药效学作用。方法30只SD大鼠随机分为生理盐水组、磺胺嘧啶银膜荆组、磺胺嘧啶银达克罗宁复层膜剂组，每组10只。采用将大鼠脱毛区置于850C恒温水浴中15S的方法制成10％体表面积浅Ⅱ度烫伤模型，观察用药前后的心率、痛阈变化以及创面愈合时间、愈合率等。结果磺胺嘧啶银达克罗宁复层膜剂对大鼠心率的初期影响较小，之后心率略有下降。同时该膜剂还能显著提高痛阈。对于创面愈合的

2、平均时间，磺胺嘧啶银达克罗宁复层膜相对于磺胺嘧啶银膜剂略显优势，前者为(19．5±1．02)d，后者为(21±1．18)d。在第20天，磺胺嘧啶银达克罗宁复层膜剂组烫伤大鼠的痊愈率为90％。结论磺胺嘧啶银达克罗宁复层膜剂在延续磺胺嘧啶银膜剂强效的皮肤烫伤修复作用的同时又具有镇痛、促进创面愈合的作用。关键词：磺胺嘧啶银达克罗宁复层膜；浅Ⅱ度烫伤；心率；痛阈doi：10．11669／epj．2013．15．009中图分类号：R969文献标志码：A文章编号：1001—2494(2013)15—1271一o4Pharmacodynamicso

3、fSulfadiazineSilver-DyclonineCompositeFilmfortheTreatmentofSuperficiallIDegreeBurnHUANGMin-yan，CHENXia，LINMiao，ZHUQian(TheFirstPeoplesHospitalofNantong，Nantong226001，China)ABSTRACT：OBJECTIVEToexplorethepharmacodynamicsofsilversulfadiazine—dycloninecompositefilmforthetre

4、atmentofSU—perficial1Idegreeburninrats．METHODSThirtySDratswererandomlydividedintonormalsalinegroup，silversulfadiazinefilmgroupandsilversulfadiazine—dycloninecompositefilmgroup(n=10ineachgroup)．Thehairremovalareaofratswasscaldedin85℃waterbathfor15s．producingsuperficialⅡd

5、egreeburnmode1．Theheartratesbeforeandafterthemedication，changesofpainthreshold．woundhealingandcureratewereobserved．RESULTSSilversulfadiazine—dycloninecompositefilmhadlittleinfluenceontheheartrateintheearlyperiod，however，theheartratedecreasedslightlysoonafterwards．Silver

6、sulfadiazine—dycloninecompositefilmincreasedthepainthresholdsignificantly．Comparedtosilversulfadiazinefilm，silversulfadiazine—dycloninecompositefilmhadalittleadvantageontheaveragetimeforwoundhealingwhichwere(19．5±1．02)dforthecompositefilmand(21±1．18)dfortheotherone．Onth

7、e20thday，thecurerateofsilversulfadiazine—dycloninecompositefilmwas90％．CONCLUSIONSilversulfadia-zinc—dycloninecompositefilmalsohasskinburnrepairactionassilversulfadiazinefilm，andithasanalgesiseffectandcanpromotewoundhealing．KEYWORDS：silversulfadiazine—dycloninecompositef

8、ilm；superficialⅡdegreeburn；heartrate；painthreshold磺胺嘧啶银于20世纪6O年代末开始应用于烧白，梁蓉等将烫创油加入磺胺嘧啶银霜剂中等。烫伤创面治疗J，是目前国内外广泛应用