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1、衡阳地区女性生殖道支原体感染状况及药物敏感性分析[摘要]目的：了解衡阳地区女性生殖道支原体感染状况及其对药物的敏感性，以指导临床合理使用抗菌药物。方法：应用商业化的试剂盒,对2690份女性生殖道标本进行支原体培养和药物敏感试验。结果：女性泌尿生殖道感染患者的支原体总感染率为48.3%(1299/2690)。解脲支原体(Uu)单独感染率最高(31.7%,852/2690),解脲支原体和人型支原体(Uu-Mh)混合感染率居中(7.25%,195/2690)，人型支原体(,Mh)单独感染率最低(4.54%,122/2690)。药敏试验结果表明,Uu仅仅对交沙霉素、普那霉素、强力霉素及克拉霉素
2、敏感性较好，分别为95.9%,95.3%,94.0%,82%.Mh仅仅对强力霉素、普那霉素、交沙霉素敏感性较好，分别为97.5%,96.7%,95.9%.Uu-Mh仅仅对强力霉素、普那霉素、交沙霉素敏感性较好，分别为91.8%,90.3%,88.2%.结论：本地区妇女生殖道支原体感染率较高，且发现存在多种耐药现象。由于支原体耐药存在地区的差异，为了防止治疗失败，在治疗前进行药敏实验是必要的。关键词：生殖道感染解脲支原体人型支原体药物敏感性中图分类号：R691.3文献标识码：APrevalenceandantimicrobialsusceptibilityofMycoplasmahomi
3、nisandUreaplasmaurealyticuminChinesewomenwithgenitalinfectiousdiseasesfromHengyang[Abstract]Objective：thisstudyistoinvestigatethecharacteristicsofUUandMHprevalenceanditsantimicrobialsusceptibilityinchinesewomenwithgenitalinfectionfromHengyang. Methods:Byusingcommercialmycoplasmastrips,weinvestig
4、atedtheincidenceandantimicrobialresistanceofUUandMHin2690ChinesewomenwithgenitalinfectionbetweenJanuary2009andDecember2012inHengyangChina. Results: (1)Theoverallpositiveincidenceofgenitalmycoplasmaswas48.3%.ThemostcommonpatternwasUUmonoinfection(31.7%,892/2690),theUU-MHcoinfectionpatternrankedse
5、cond(13.91%)andMHmonoinfectionwaslowest(1.71%).However,asignificantlyhigherinfectionratebygenitalmycoplasmaswasfoundinyoungwomen(agerange:16-35years).(2)Overall,Uususceptibilityratesremainedhighonlytojosamycin(95.9%),pristinamycin (95.3%),doxycycline(94.0%),andclarithromycin(82.0%),whileMhhadhig
6、hsusceptibilityratesonlytodoxycycline(97.5),pristinamycin(96.7%),josamycin(95.9%).AndUU-MH-mixedhadhighsusceptibilityratesonlytodoxycycline(91.8%),pristinamycin(90.3%),josamycin(88.2%X)_.Conclusions: Highinfectionratesandseveredrugresistancesofgenitalmycoplasmaswerefoundinwomenwithgenitalinfecti
7、onsinthisregion.Becauseofgeographidifferencesamongantibioticresistance,localin-vitrosusceptibilitytestingisrecommendedtoavoidfailureoftherapy.Keywords:genitalinfectiousdiseases,Ureaplasmaurealyticum,Mycoplasmahominis,antimic
