[精品]APRIL和XIAP在结肠癌、结肠腺瘤及正常结肠黏膜中的表达及意义.doc

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1、APRIL和XIAP在结肠癌、结肠腺瘤及正常结肠黏膜中的表达及意义APRIL和XTAP在结肠癌、结肠腺瘤及正常结肠黏膜中的表达及意义［摘要］目的探讨增殖诱导配体(APRIL)和X连锁凋亡抑制蛋白(XIAP)在结肠癌、结肠腺瘤及正常结肠黏膜组织中的表达及其临床意义。方法应用免疫组织化学EnVision法检测结肠癌组织标本60例、结肠腺瘤30例及正常结肠黏膜组织30例中APRIL和XTAP的表达。结果结肠癌、结肠腺瘤及正常结肠黏膜组织中APRIL和XTAP的阳性表达率均呈逐渐降低趋势，3组间APRIL和XTAP的阳性表达率比

2、较，差异有统计学意义(P〈0.01)。结肠癌组织中APRIL的阳性表达与组织分级、淋巴结转移以及浸润程度密切相关(P〈0.01)；XTAP的阳性表达与Dukes分期、淋巴结转移以及浸润程度密切相关(P<0.01)。结论APRIL和XTAP的表达增高不仅可能在正常黏膜-腺瘤-癌的病理形成过程中起一定作用，更与结肠癌浸润、转移等恶性生物学行为有密切关系。［关键词］结肠癌；结肠腺瘤；伽疫组织化学；增殖诱导配体；X连锁凋亡抑制蛋白［中图分类号］R735.3+5［文献标识码］A［文章编号］1674-4721(2014)09(a)-

3、0012-03ExpressionandclinicalsignificanceofAPRILandXTAPincoloncarcinoma,colonadenomaandnormalcolonmucosaYUANDe-hanlKANGJu-ling2SUYan-tao3WENZhi-xionglTANGHua-zhongl1.DepartmentofGeneralSurgery,ShijieHospitaiofDongguanCityinGuangdongProvinee,Dongguan523290,China；2.

4、DepartmentofPathology,theFirstAffiliatedHospitaiofJinanUniversity,Guangzhou510000,China；3.DepartmentofNursing,ShijieHospitalofDongguanCityinGuangdongProvince,Dongguan523290,China［Abstract］ObjectiveToinvestigatetheexpressionandclinicalsignificanceofaproliferation-

5、inducingligand(APRIL)andX-linkedinhibitorofapoptosisprotein(XIAP)incoloncarcinoma,colonadenomaandnormalcolonmucosa.MethodsTheexpressionofAPRILandXIAPwasdetectedbyimmunohistochemicalEnVisionTMplusnon-hiotintechniquein60casesofcoloncarcinomaand30casesofcolonadenoma

6、,30casesofnormalcolonmucosa.ResultsThepositiveexpressionratesofAPRILandXIAPincoloncarcinoma,colonadenomaandnormalcolorectalmucosadecreasedgradually.Therewassignificantdifferenceamongthethreegroups(P<0.01).TheexpressionofXIAPwerecloselyrelatedtoDukesclinicalstage,

7、lymphnodemetascasisandthedegreeofinfiltration(P<0.01).TheexpressionofAPRILwerecloselyrelatedtodifferentiationdegree,lymphnodemetascasisandthedegreeofinfiltration(P<0.01).ConclusionThehighexpressionofAPRILandXIAPmayplayimportantrolesinthecarcinogenesisofcoloncarci

8、nomaanditisinvolvedinthemetastasisandinfiltration.［Keywords］Coloncarcinoma；Colonadenoma；Immunohistochemistry；Aproliferation-inducingligand；X~1inkedinhibitorofa