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《颅痛定对心肺复苏术后患者的影响及其机制探讨.pdf》由会员上传分享,免费在线阅读,更多相关内容在应用文档-天天文库。
1、临春医学工程2014年9月第21卷第9期·l121··论著·(临床研究)颅痛定对心肺复苏术后患者的影响及其机制探讨郭明明,邹德志,刘江辉,蔡锐彬(中山大学附属第一医院急诊科,广东广州510080)【摘要】目的探讨分析颅痛定对心肺复苏术后患者的影响及其机制。方法选择32例心肺复苏术后患者并随机分为观察组与对照组各16例,所有患者均予以常规治疗,观察组在此基础增加颅痛定治疗,比较两组的临床疗效。结果观察组治疗总有效率显著高于对照组;观察组治疗后SOD显著高于对照组,MDA、TXB显著低于对照组:治疗后第1天观察组NO显
2、著高于对照组,第2天和第3天观察纽显著低于对照组;治疗后第1天观察纽CO显著低于对照组;以上差异均有统计学意义(尸<0.05)。结论颅痛定可以有效改善心肺复苏术后患者意识,降低记忆力及智力减退损害.改善缺血一再灌注损伤【关键词】颅痛定;心肺复苏术;脑缺血一再灌注损伤中图分类号:R654.1文献标识码:Adoi:10.3969/i.issn.1674—4659.2014.09.1121EffectandMechanismofRotundineintheCardiopulmonaryResuscitationGUOMi
3、ngming,ZOUDezhi,LIUJianghuiCAIRuibin(EmergencyDepartment,theFirstAfiliatedHospitalofSunYat-senUniver-sity,Guangzhou510080,China,.Correspondingauthor:LIUJianghui,E-maiL"llhbao@126.com)【Abstract]ObjectiveToexploretheefectandmechanismofrotundineinthecardiopulmona
4、ryresuscitation.Methods32patientswithcardiopulmonaryresuscitationinourhospitalwererandomlydividedintotwogroupsequally.Allpatientsreceivedroutinetherapy,andpatientsintheobservationgroupreceivedrotundineadditionally.Theclinicalefectwascomparedbetweenthetwogroups
5、.ResultsThetotalefectiverateofobservationgroupwassignificantlyhigherthanthatofcontrolgroup.SODaftertherapyoftheobservationgroupwassignificantlyhigherthanthatofthecontrolgroup,andMDAandTXB2weresignificantlylowerthanthoseofthecontrolgroup.NOlevelatthefirstdayoft
6、herapyintheobservationgroupwassignificantlyhigherthanthatinthecontrolgroup,butNOlevelatthesecondandthethirddayoftherapywassignificantlylowerthanthatofthecontrolgroup.ConclusionsInthecardiopulmonaryresuscitation,rotundineCanimprovetheconsciousnessofpatients,red
7、ucethedamageoflossofmemo~andintelligence,andimproveischemiareperfusioninjury.【Keywords】Rotundine;Cardiopulmonaryresuscitation(CPR);Ischemiareperfusioninjury心肺复苏术(cardiopulmonaryresuscitation,CPR)在临床女8例;年龄38—72岁,平均年龄(58.6-I-9.8)岁;按脑缺上广泛应用于心脏暂停患者的抢救,是目前最为简单廉价有血时
8、间,少于5min者2例,5~10rain者5例,l0~15min效、易于学习和掌握的救命技术[13。随着CPR技术的熟练应者7例,15min以上者2例。对照组中男7例,女9例;年龄用,近年来成功率有了明显的提高。但CPR最后成败的关键还40—75岁。平均年龄(59.3±10.6)岁;按脑缺血时间,少于在于脑复苏_2l。在CPR的过程中.脑组织经历了心跳骤停后
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