高敏C-反应蛋白与免疫功能检测在肺炎支原体肺炎中的意义-论文.pdf

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1、·456·临床儿科杂志第32卷第5期2014年5月JClinPediatrVo1．32No．5May．2014doi：10．3969／j．issn．1000-3606．2014．05．015论著·高敏C．反应蛋白与免疫功能检测在肺炎支原体肺炎中的意义楚文英徐慧高淑青姜采荣包头市第四医院儿科(内蒙古包头014030)摘要：目的探讨高敏C一反应蛋白(hs—CRP)联合免疫功能检测在儿童肺炎支原体肺炎(MPP)中的临床意义。方法选取单纯MPP患儿103例，分为全身炎症反应综合征(SIRS)组47例和非SIRS组56例，另取26例健

2、康儿童作为对照组，检测hs—CRP、体液免疫指标及细胞免疫指标。结果SIRS组和非SIRS组的血清hs—CRP、IgG、IgM、CD8水平显著高于对照组，而IgA、CD3+．CD4+、CD4+／CD8’水平显著低于对照组，差异均有统计学意义(P均<0．05)；SIRS组的hs—CRP、IgG显著高于~SIRS组，而IsA、CD3、CD4、CD4+／CD8水平则显著低于非SIRS组，差异均有统计学意义(P均<0．O5)lSIRS组和非SIRS组的IgM与CD8水平的差异则无统计学意义(尸>0．05)。结论MPP患儿的体液免疫及

3、细胞免疫功能均有紊乱，且与病情有关；hs—CRP有助于判断儿童MPP病情程度。关键词：肺炎支原体肺炎；免疫功能；高敏c一反应蛋白；儿童ClinicalsignificanceofhighsensitiveC-reactiveproteinandimmunefunctioninchildrenwithMycoplasmapneu—moniaepneumoniaCHUWenying,XUHui,GAOShuqing,JIANGCairong(DepartmentofPediatrics，TheFourthHospitalofBa

4、otou,Baotou014030,InnerMongoliaAutonomousRegion,China)Abstract：0bjectivesTodetecttheclinicalsignificanceofhighsensitiveC—reactiveprotein(hs-CRP)andimnlllnefunctioninchildrenwithMycoplasmapneumoniaepneumonia(MPP)．Methods103childrenwithMPP,47casesofsystemicinflammato

5、ryresponsesyndrome(SIRSgroup)，56casesofnon—systemicinflammatoryresponsesyndrome(non—SIRSgroup)wererecruited．26healthychildrenservedasthecontrolgroup．ELISAwasusedtodetectthelevelofserumhs—CRP,immunein—dexes，IgG，IgA，andIgM，CellularimmuneCD3，CD4，CD8，CD4+／CD8．ResultsTh

6、elevelofserumhs—CRP、IgG、IgMandCD8incontrolgroupweresignificantlylowerthanthoseinnon—SIRSgroupandSIRSgroup(P<0．05)．ThelevelofIgA、CD3，CD4，CD4+／CD8incontrolgroupweresignificantlyhigherthanthoseinnon—SIRSgroupandSIRSgroup(P<0．05)．Thelevelofserumhs—CRP、IgGinSIRSgroupwer

7、esignificantlyhigherthanthoseinnon-SIRSgroupfP<0．05)．111elevelofIgA、CD3、CD4、CD4+／CD8inSIRSgroupweresignificantlylowerthanthoseinnon-SIRSgroup．Therewasnosignificantdiferenceinnon—SIRSgroupandSIRSgroupofIgMandCD8+(P>0．05)．Thelevelchangeofserumhs—CRPwerepositivelyrela

8、tedwithIgG(r=0．66，P=-0．001)andwerenegativelyrelatedwithIgA、CD4、CD4／CD8(，=0．79，O．67，O．82，Pallwere