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时间:2020-05-18
《通过η~3-苄基钯中间体零价钯催化的吲哚苄基化反应(英文).pdf》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、ChineseJournalofCatalysis36(2015)15—18催化学报2015年第36卷第1期fWxArW.chxb.cnavai“薯■瓣⋯鲫曩蠢ll一一∥一“¨=jour囊lhagewwl鬟{ee9;m/Ioae,cihjflj零Communication(SpecialIssueonCatalysisinOrganicSynthesis)Pd(O)-catalyzedbenzylationofindolethroughq3-benzylpalladiumintermediateZheng-LeZhao一QingGub,Xin—YanWu,Shu-
2、LiYou.b,#aKeyLaboratory厂0rAdvancedMaterialsandInstituteofMneChemicals,EastChinaUniversityofScienceandTechnology,Shanghai200237,ChinabStoteKeyLaboratoryofOrganometollicChemistry,ShanghaiInstituteofOrganicChemistry,ChineseAcademyofSciences,Shanghai200032,ChinaARTICLEINF0ABSTRACTArticleh
3、istory:AnefficientmethodhasbeendevelopedforthePd(O).catalyzedbenzylationofindoles,whichoc.Received13June2014curredwithexclusiveregioselectivity.Whentl1isreactionwasperf0rmedinthepresenceofAccepted3July2014Pd(PPh3)4,itprovidedaccesstoabroadrangeofsubstitutedindolesbearingdiarylmethanes
4、atPublished20January2015their3-positionin90%一99%yieldsundermildconditions.@2015,DalianInstituteofChemicalPhysics,ChineseAcademyofSciences.PublishedbyElsevierB.Allrightsreserved.Keywords:BenzylationIndoleTriarylmethaneT13-BenzylpalladiumintermediateThechemistryofⅡ.allylpalladiumcomplex
5、eshasbecomecarboxylates[11—15】andevenfluorides【16],toPd(O).Benzyloneofthemostsuccessfulareasoforganicsynthesis.asexem.chloridescanalsobetreatedascommonprecursorsfortheplifiedbytheTsuji—Trostreactionf11.Incontrast,reactionsformationofq3-benzylpalladiumspeciesbecausethevareinvolvingtheq
6、3一benzylpalladiumcomplexesgeneratedfromreadilyavailablewithvariouscommercia1suppliersandstablebenzylicderivativesaremuchlesscommonbecausetheyre—【17—271.Severalelegantpalladium—catalyzedbenzylationpro·quirethedearomatizationofanarylsystem.Despitethediffi.cesseshavebeendevelopedduringth
7、ecourseofthelastdec.cultiesassociatedwiththepreparationofq3一benzylpalladiumbenzyliccomplexes.thesesystemsareconsideredtobeusefulinterme—,Pd,diatesinorganicsynthesis.becausetheycanbeusedasspecial一。/orthoorth口110_allyl-palladiumspecies.Inthisway,q3.benzylpalladium,、、、Pd一、intermediatesha
8、vebee
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