载超顺磁性氧化铁高分子液态氟碳纳米粒的制备及体外显像-论文.pdf

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1、·674·中国介入影像与治疗学2013年第1O卷第11期ChinJIntervImagingTher，2013，Vol10，No11基础与实验研究Preparationandimaginginvitroforperflu0r0hexane。encapsulatedsuperparamagneticpoly(1actic。。CO。。glycolicacid)__ironoxidemultifunctionalultrasoundcontrastagentsWANGMin，RANHai—tao’“，WANGZhi—gang，W己，Wei，WANGQi，SUNYang

2、’。(1．InstituteofUltrasoundImaging，ChongqingMedicalUniversity，Chongqing400010，China；2．DepartmentofUltrasonography，theSecondAffiliatedHospital，ChongqingMedicalUniversity，Chongqing400010，China)[Abstract]0bjectiveTopreparemulti-modecontrastagent，andtoinvestigateitseffectforultrasoundandM

3、Rimaginginvitro．MethodsDoubleemulsionmethodwasusedtoprepareperfluorohexane-encapsulatedsuperparamagneticpoly[1actic-co—glycolicacid，PLGA]一ironoxide(s—PFH／PLGA)，anditsmorphology，size，Fe304loadingcapacityandphotoac—cousticdetectionwereassessed．Then，theprepareds—PFH／PLGAmicrocapsuleswer

4、eappliedwithdifferentconcentra—tionstoperformultrasoundimaging，andtheechogenicitywasassessedpostirradiationusingJC200focusedultrasoundtumortherapysystem．Thens—PFH／PLGAmicrocapsuleswerealsoappliedtoperformMRimaginginvitro，andthesignalintensitywascalculated．ResultsThes—PFH／PLGAmicrocap

5、suleswereobservedwithregularsphericalmorphology，theaveragesizewas(738．9士158．4)nm，averageelectricpotentialwas(一15．9士6．9)mY，andphotoaccousticsignalcouldbedetected．Invitro，s-PFH／PLGAmicrocapsulesshowedhyperechogenicityinUSimagingwhichincreasedafterHIFUirra—diation．InMRI，s—PFH／PLGAnegati

6、velyenhancedonT2WI，andthesignalintensitydecreasedwiththeincreaseofironcontent．ConclusionTheprepareds—PFH／PLGAmicrocapsulescansuccessfullyactascontrastagentofultrasoundandMRimaginginvitro．[-Keywords]ultras0nography；Contrastmedia；Magneticresonanceimaging载超顺磁性氧化铁高分子液态氟碳纳米粒的制备及体外显像王敏一，冉海

7、涛，王志刚，吴伟，王琦，孙阳，(1．重庆医科大学超声影像学研究所，重庆400010；2．重庆医科大学附属第二医院超声科，重庆400010)[摘要]目的制备一种能同时用于超声造影及MR成像的多模态造影剂，观察其体外成像效果。方法采用双乳化法合成载超顺磁性氧化铁(SPIO)纳米颗粒及全氟己烷(PFH)的高分子微球(s—PFH／PLGA)，检测其一般特性及光声信号。对不同浓度的s—PFH／PLGA水囊模型进行超声显影，以JC2oo聚焦超声肿瘤治疗系统辐照后观察回声强度变化；对不同铁含量的s—PFH／PLGA进行MR成像。结果透射电镜下s—PFH／PLGA呈球形，SPI

8、O颗粒均匀分布在外壳上，