糖复合物的生物应用.pdf

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1、第43卷第3期江汉大学学报（自然科学版）Vol.43No.32015年6月J.JianghanUniv.（Nat.Sci.Ed.）Jun.2015GlycoconjugatesforBiologicalApplicationsDINGFei，LUWangting（InstituteforInterdisciplinaryResearch，JianghanUniversity，Wuhan430056，Hubei，China）Abstract：Glycansareaclassofpotentialsignalmolecules，theyexpressontheforefronts

2、urfaceofcellsandparticipateinmanykeybiologicalprocessesviaformattingvariousglycoconjugates.Mainlydiscussestherecentdevelopmentofglycoconjugatesincontrollingdrugtargetingdeliveryandcancercellimaging/detection.Overviewstheglycoconjugatesoffolate，oligosaccharidesastargetingmoietyindrugtargetin

3、gdeliverysytstem.Meanwhile，elaboratesthevariousglycoconjugatesintumorimaging/sensing，andpointsoutthefutureprospectsofglycoscience.Keywords：glycoconjugates；folate；oligosaccharides；drugtargetingdelivery；tumorimaging/sensing糖复合物的生物应用丁菲，鲁望婷（江汉大学交叉学科研究院，湖北武汉430056）摘要：糖类化合物是一类很重要的生物大分子，它在细胞膜表面通过形

4、成各种复合物参与许多重要的生理活动。主要讨论了近几年糖类复合物在药物靶向传递及肿瘤成像/检测等方面的研究进展，综述了叶酸、寡糖等作为靶向基团的药物靶向传递体系，同时探讨了各种糖类复合物在细胞成像及生物检测方面的应用，指出了未来糖化学的发展前景。关键词：糖复合物；叶酸；寡糖；药物靶向传递；癌细胞成像/检测中图分类号：Q71文献标志码：A文章编号：1673-0143（2015）03-0242-06DOI：10.16389/j.cnki.cn42-1737/n.2015.03.0090IntroductionGlycansboundwithproteinsorlipidsviaco

5、valentbondsweredefinedasglycoconjugates，containingglycopro⁃teins，proteoglycansandglycolipids.Almostacenturyago，theGermanscientistOttoWarburgobservedthatcancer⁃oustissuesconsumelargeamountsofglucosecomparedtonon-transformedtissueandhavehighratesofaerobicgly⁃［1-2］［3］colysis，whichisknownastheW

6、arburgeffect.Thisisrecognizedasoneofthelandmarkofcancer.Glycolyticenzymes，aswellastheinsulin-independentglucosetransporterGLUT-1，arewidelyoverexpressedinhumancan⁃［4-5］cersandhighexpressionlevelsoftheseproteinsintumorbiopsysamplescorrelatewithpoorcancerprognosis，［6-9］makingthempromisingthera

7、peutictargets.1ConjugatesforDrugTargetingDeliveryDeliveringacancerdrugtoitsproposedsiteselectivelyhasobvioustherapeuticadvantages，includingreducedReceived：2014-09-18Biography：DINGFei（1984—），female，assistantresearcher，doctor，majorsinmedicalchemistryandmol