间充质干细胞移植治疗终末期肝病前后血清甲胎球蛋白的变化.pdf

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1、分子诊断与治疗杂志2015年3月第7卷第2期JMolDiagnTher．March2015．Vo1．7No．2·论著·间充质干细胞移植治疗终末期肝病前后血清甲胎球蛋白的变化陈建华徐玉琴杨晋辉s张军[摘要]目的探讨问充质干细胞(mesenchymalstemcell，MSC)移植治疗终末期肝病甲胎球蛋白(OL—fetoprotein，AFP)的变化，观察病人肝功能有无改善。方法MSC移植治疗73例终末期肝病患者，其中包括失代偿期肝硬化患者45例，慢性重症肝炎5例，监测疗前和疗后1周、疗后1个月、2个月AFP及肝功能变化。结果疗后1周AFP较疗前明显升高

2、，其后降低，2个月至疗前水平，差别有统计学差异(P<0．05)。白蛋白(serumalbumin，ALB)疗后1月、2月与疗前相比，差别有统计学意义(P<0．0s)。胆碱酯酶疗后2月较疗前明显升高，差别有统计学意义(P

3、entofend—stageliverdiseaseCHENJianhua，XUYuqin，YANGJinhui。，ZHANGJun(1．DepartmentofPharmacology，SchoolofPharmacy，NorthSichuanMedicalCollege，Nanchong，Sichuan，China，637000；2．TheInfectiousDepartment，No．211HospitaloftheChinesePeople’SLiberationArmy，Harbin，Heilongjjiang，China，150030；3

4、．DigestiveInternalMedicine，SecondAfiliatedHospitalofKunmingMedicalUniversity，Kunming，Yunnan，China，650000；4．TheLifeHealthDepartmentofShenzhenBeikeBiotechnologyCompany，Shenzhen，Guangdong，China，518057)【ABSTRAC_r】ObjectiveToexplorethechangesof—fetoprotein(AFP)inend—stageliverdiseas

5、eaftermesenchymalstemcell(MSC)transplantationandobserveWhetherpatient’Sliverfunctionhadbeenimproved．Methods73patientswithendstageliverdiseaseweretransplantedwithMSC，including45decompensatedhepaticcirrhosisand5chronicseverehepatitispatients．TheserumlevelsofAFP．1iverfunctionweree

6、xamined1weekbeforetreatmentandlweek，lmonth，and2monthsaftertreatment．ResultsThe1evelofAFPincreasedat1weekaftertreatment，andreturnedtonormalleve12monthslater．TherewasstatisticaldifferencebetweenbeforetreatmentandaftertreatmentfP<0．05)．Theresultsrevealedastatisticallysignificantdi

7、fferencebetweenbeforetreatmentandafterl，2monthstreatmentinserumalbumin(ALB)<0．05)．Likewise，therewassignificantdifferencebetweenbeforetreatmentandafter2monthstreatmentinCholinesterase<0．05)．Nopersonsufferedfromanyothertumorunderthoroughobservation．ConclusionMSCtransplantationiSa

8、safeandeffectiveinthetreatmentofend—stageliverdisease．