淋巴细胞主动免疫治疗复发性流产40例临床分析.pdf

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1、《中国医学创新》第12卷第11期(总第329~)2o15年4月经验交流·Jingyanjiaoliu淋巴细胞主动免疫治疗复发性流产4O例临床分析杜晓丽①【摘要】目的：探讨采用淋巴细胞主动免疫治疗复发性流产(RSA)的临床疗效。方法：将临床筛查确诊为封闭抗体缺乏所致的复发性流产患者8O例随机分为治疗组和对照组各40例，治疗组采用其配偶外周血淋巴细胞进行主动免疫治疗(LIT)，对照组采用传统保胎治疗(黄体酮加hCG)，比较两组的妊娠结局。结果：治疗组妊娠成功32例，成功率为80％，其中足月分娩l6例(50％)，妊娠中晚期16例，8例流产

2、；对照组妊娠成功16例，成功率为4O％，其中足月分娩6例(37．5％)，妊娠中晚期10例，24例流产，两组比较差异有统计学意义(P

3、entSpontaneousAbortionUsingLymphocytesActiveImmunotherapy／DUXiao—liJ／MedicalInnovationofChina，2015，12(11)：131—133【Abstract】objective：Toinvestigatetheclinicaleficacyofrecurrentspontaneousabortion(RSA)usinglymphocytesactiveimmunotherapy．Method：80casesofpatientswithRSAwhi

4、chwerediagnosedbyblockingantibodyscreeningwererandomlydividedintothetreatmentgroup(40patients)andthecontrolgroup(40patients)．ThepatientsinthetreatmentgroupweretreatedbyLITwithperipheralbloodlymphoeytes，thepatientsinthecontrolgroupwithtraditionalmiscarriagetreatment(pro

5、gesteroneplushCG)，thenthepregnancyoutcomeswerecompared．Result：Inthetreatmentgroup，32casesofpregnancyweretreatedsuccessfully，andtheSuccessratewas80％，including16patientswithfull-termdelivery(50％)，16caseswithlatepregnancy，8casesofabortion．Inthecontrolgroup，therewere16case

6、swithsuecessfLdpregnancy，theSUCCESSratewas40％，includingsixCaseswithtermbirth(37．5％)，10caseswithlatepregnancy，24casesofabortion．Bycomparison，thereWassignificantdifferenceinthetwogroups(P<0．01)．Afterimmunotherapy，34patientsbecamepositiveblockingantibodies，including29case

7、sofpregnancysuccess，aSuccessrateof85-3％；sixeasesofblockingantibodieswerestillnegative，twocaseswithpregnancySUCCESS，theSuccessratewas33-3％，respectively，thedifferencetherewasstatisticallysignificant(P

8、afe，efective，andreliableclinicalvalue．【Keywords】Blockingantibodies；Recurrentspontaneousabortion；Lymphocytes；Immunothe