拉坦前列腺素对原发性开角型青光眼患者的疗效.pdf

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1、第40卷第7期贵阳医学院学报Vo1．40No．72015年7月JOURNALOFGUIYANGMEDICALCOLLEGE2015．7拉坦前列腺素对原发性开角型青光眼患者的疗效高文清(广元市第一人民医院，四川广元628017)[摘要]目的：研究拉坦前列腺素对原发性开角型青光眼(POAG)患者的治疗效果。方法：POAG患者135例，随机分为观察组(n：70)和对照组(n=65)，观察组给予拉坦前列腺素治疗，对照组给予噻吗心安治疗；记录2组患者治疗前后的眼压及波动值、视野缺损及视网膜纤维层(RNFL)厚度及不良反应。结果：两组患者治疗后昼夜平均眼压、眼压

2、波动值及视野缺损范围均较治疗前明显降低，差异有统计学意义(P<0．05)；治疗后观察组昼夜平均眼压、眼压波动值较对照组降低更明显，下方视野、颞侧视野及鼻侧视野缺损范围较对照组明显缩小．上方视盘、下方视盘、颞侧视盘及鼻侧视盘较对照组明显增厚，差异均有统计学意义(P<0．05)；治疗后观察组9例(12．86％)、对照组11例(16．92％)出现不良反应，差异无统计学意义(P>0．05)。结论：拉坦前列腺素治疗原发性开角型青光眼效果优于噻吗心安。【关键词]拉坦前列腺素；噻吗心安；青光眼，开角型，原发性；眼压；视盘[中图分类号]R775．2[文献标识码]A[

3、文章编号]1000-2707(2015)07-0760-03TheCurativeEfectofLatanoprostonPatientswithPrOpen-angleGlaucomaGAOWenqing(GuangyuanNo．People’SHospital，Guangyuan628017，Sichuan，China)[Abstract]Objective：Toobservetheeffectoflatanoprostonpatientswithprimaryopen—angleglau—coma．Methods：Atotalof135pati

4、entswithprimaryopen—angleglaucomawereenrolledinthisstud-Y．Allthecaseswererandomlydividedintoobservationgroupandcontrolgroup．Theobservationgroup(70cases)weretreatedwithlatanoprostwhilethecontrolgroup(65cases)weretreatedwithtimololmaleate．TheIOP，visualfielddefectsaswellasthethick

5、nessoftheretinalfiberlayer(RN—FL)weremeasuredandrecorded．Andtheuntowardeffectswerealsoobserved．Results：Aftertreat—ment，24hmeanIOP，IOPfluctuationvalueandtheextentofvisualfielddefectsintwogroupweresignificantlydecreased，andthedifferencesbetweenbeforetreatmentandaftertreatmentwere

6、statisti-callysignificant(P<0．05)．Comparedwithcontrolgroup，aftertreatment，24hmeanIOP，IOPfluctuationvaluedecreasedmoresignificantly，theextentofbelowvisualfielddefect，temporalvisualfielddefectandnasalvisualfielddefectsignificantlyreduced，andaboveopticdisc，belowopticdisc，temporalo

7、pticdiscandnasalopticdiscsignificantlythickenedinobservationgroup(P<0．05)．Therewere9cases(12．86％)adversereactionsinobservationgroupwhile1tcases(16．92％)incontrolgroup，andthedifferenceswerenotstatisticallysignificant(P>0．05)．Conclusion：Latano—prostisbetterthantimololmaleateintrea

8、tmentofprimaryopen—angleglaucoma．[Keywords]latanoprost