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时间:2020-05-09
《边缘性脑炎的研究进展.pdf》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、1j1Jj1J1J脑与神经疾病杂志2012年第2O卷第3期239在神经肿瘤研究中,随着对MMPs在胶质细胞瘤发生、发[8]Lampc~K,MacheinU,MacheinMR,eta1.Expressionofmatrixmetalloproteinasesandtheirtissueinhibitorsinhumanbraintumors.展及侵袭过程中作用机制和与血一脑屏障、血一脑脊液屏障关系AmJPathol,1998,153:429437.的明晰,以及在临床检测技术与方法上的提高,将MMPs的表[9]RomeC,ArsautJ,TarisC,eta1.MMP
2、-7(matrilysin)expressionin达水平作为临床辅助诊断的指标,同时开发并研制出各种抑制humanbraintumors.MolCarcinog,2007,46:446452.MMPs表达的药物,其临床应用预计有良好的前景。[10]SarkarS,Nutta11RK,LiuS,eta1.Tenasein-Cstimulatesgliomacell参考文献invasionthroughmatrixmetalloproteinase一12.CancerRes,2006,66:1177l—l1780.JohnsonN,AhonenM,KahariVM.M
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4、fmatrixineaneerprogression.NatRevCancer,2002,2:161·174.metalloproteinase(MMP)一12bymyofibroblastsduringalkali-bumedCoussensLM,FingletonB,MatrisianLM.Matrixmetalloproteinasecornealwoundhealing.CurrEyeRes,2009,34:207-214.inhibitorsandcancer:trialsandtribulations.Science,2002,295:[13]Raith
5、athaSA,MuzikH,MuzikH,eta1.Localizationofgelatinase—2387—2392Aandgelatinase—BmRNAandproteininhumangliomas.Neuroon—MassovaI,KotraLP,RafaelF,eta1.Matrixmetalloproteinases:col,2000,2:145.150.structure,evolution,anddiversification.FASEBJ,1998,12:[14]杨小立,王茂德,刘守勋,等.人脑胶质瘤基质金属蛋白酶_9的表l075.1095达与
6、肿瘤血管形成的相关性及对其肿瘤防治的意义.中国临床康MauvielA.Cytokineregulationofmetalloproteinasegeneexpression.复,2004,8:4779-4781.JCellBiochem,1993,53:288-295[15]ParkMJ,KimMS,ParkIC,eta1.PTENsuppresseshyaluronicZuckerS,DoshiK,CaoJ.Measurementofmatrixmetalloproteinasesacid—inducedmatrixmetalloproteinase-9expre
7、ssioninU87MG(MMPs)andtissueinhibitorsofmetalloproteinases(TIMP)inglioblastomacellsthroughfocaladhesionkinasedephosphorylation.bloodandurine:potentialclinicalapplications.AdvClinChem,CancerRes,2002,62:6318-6322.2004,38:37—85.[16]NakanoA,TaniE,MiyazakiK,eta1.Matrixmetalloprotelnasesand
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