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时间:2020-05-09
《阿胶对围绝经期大鼠卵巢颗粒细胞凋亡及Bcl-2和Bax表达的影响.pdf》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、2015,Vo1.32,No.3药物研究阿胶对围绝经期大鼠卵巢颗粒细胞凋亡及Bc1.2和Bax表达的影响汝文文,和娴娴,钤莉妍,孙阳恩,韩丽,王东亮(山东东阿阿胶股份有限公司,国家胶类中药工程技术研究中心,山东聊城252201)[摘要]目的:探讨阿胶对围绝经期大鼠卵巢颗粒细胞凋亡及其相关基因Bcl-2和Bax表达的影响。方法:选用4月龄雌性大鼠为正常对照组,14月龄阴道细胞学表现为动情期延长的雌性大鼠为衰老大鼠模型。模型动物随机分别给予阿胶或戊酸雌二醇片治疗。采用原位末端核苷酸标记法(TUNEL)检测卵巢细胞凋亡,免疫组化法检测细胞凋亡相关因子Bel-2,Bax。结果:阿胶高、中
2、、低剂量组卵巢细胞凋亡阳性表达与模型组比较有显著性差异,同时可使卵巢凋亡基因Blc-2表达增强,促凋亡基因Bax表达减弱,Bel-2/Bax比例增加。结论:阿胶通过抑制Bax蛋白的表达,上调Bcl-2蛋白表达,抑制卵巢颗粒细胞凋亡,进而改善卵巢功能。[关键词]阿胶;围绝经期大鼠;细胞凋亡;Bcl-2;Bax[中图分类号]R282[文献标识码]A[文章编号]2095—3593(2015)03—0147—04EfectsofCo//aCoriiAsinionOvarianGranulosaCellsApoptosisandExpressionofBcl-2andBaxinPerime
3、nopausalRatsRUWen—wen,HEXian—xian,QIANLi—yan,SUNYang—en,HANLi,WANGDong—liang(ShandongDong—EE-JiaoCo.,Ltd.,NationalEngineeringTechnologyResearchCenterofRubberMedicine,ShandongLiaocheng252201,China)[Abstract]Objective:TostudytheeffectsofCollaConiAsinionovariangranulosacellsapoptosisandexpressio
4、nofBc1-2andBaxinpefimenopausalrats.Methods:SDfemaleratsof4monthsoldweresettobethenormalcontrolgroupandSDfemaleratsof14monthsoldwhoseoestruselongationincolpocytologyappearanceweresetasthesenilefemaleratmode1.Theseratsweredividedinto5groupsrandomly,asfollows:highdoseCollaCoriiAsinigroup,middled
5、oseCoUaCoriiAsinigroup,lowdoseCollaConiAsinigroup,estradiolvalerategroup,modelgroup.After8weeksintheinterventionperiod,ovarianapoptosisandtheexpressionofovariangranulosacellBcl-2.BaxweremeasuredbyTUNELandimmunohisto-chemistrymethods.Results:Highandmiddledosec0ffnConiAsinigroupscouldde-creasea
6、poptosisinovariangranulosecells(P<0.05),andcouldimprovetheexpressionofBcl-2intheovariesandweakenedtheex—pressionofBax,whichthenincreasetheratioofBcl-2/Bax.Conclusion:CollaCoriiAsinicoulddelayovariangranuloseceilsapoptosisthroughinhibitingtheexpressionofBax,increasingtheexpressionofBel-2during
7、perimenopausalperiod,whichmightbeonereasonofCollaCoriiAsinipostponedtheovarianfailureandcuredperimenopausalsyndrome.[KeyWords]CollaCodiAsini;Perimenopausalrats;Cellsapoptosis;Bcl一2;Bax围绝经期综合征(perimenopausalayndrome,PMS)骨质疏松的一组征候群。阿胶为马科动物驴(“是指
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