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时间:2020-05-08
《急性冠脉综合征抗栓和抗凝治疗对纤溶系统和内皮细胞功能影响-论文.pdf》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、临床研究Linchuangyanjlu《中国医学创新》第11卷第8期(总第290~J)2014~3月急性冠脉综合征抗栓和抗凝治疗对纤溶系统和内皮细胞功能影响王小军①【摘要】目的:探讨急性冠脉综合征患者使用低分子肝素治疗对纤溶系统和内皮细胞功能的影响。方法:选取本院就诊的54例急性冠脉综合征患者,设为ACS组,将ACS组按照随机数字表法分为治疗组和常规组两个亚组,每组27例,另取同期在本院健康体检者54例,设为对照组。常规组患者使用常规抗凝药、他汀类和钙离子拮抗剂等,治疗组患者在常规组的基础上加用低分子肝素。比较ACS组和对照组、常规组和治疗组tPA、PAI一
2、1和vWF含量。结果:ACS组的tPA、PAI一1和vWF含量与对照组比较差异均有统计学意义(P3、ls/WANGXiao-jun.//MedicaiInnovationofChina.2014.11(08):092-093【Abstract】Objective:Toexploretheclinicaleffectonfibrinolyticsystemandendothelialfunctionoflowmolecularhepafinintreatmentoftheacutecoronarysyndrome.Method:Fifty—fourpatientswerechosentobetheACSgroupinthehospita1.TheACSgro4、upwasrandomlydividedintotwogroups.Theobservationgroupandthenormalgroupbothh'ad27patients.Fifty—fourhealthypeoplewerechosentobethecontrolgroupduringthesametime.Thenormalgroupwastreatedwithanticoagulant,statinsandcalciumantagonists.Theobservationgroupwastreatedwithlowmolecularheparin5、basedonthesametreatmentofthenormalgroup.TohadacomparisonbetweenthesethreegroupsofthetPA,PAI-tandvWF.Result:ThetPA,PAI—landthevWFoftheACSgroupweredifferentwiththecontrolgroup,andthediferencebetweenthetwogroupswereallstatisticallysignificant(P6、iongroupwerediferentwiththenormalgroup,andthediferencebetweenthetwogroupswereaIlstatisticallysignificant(P<0.05).Conclusion:LowmolecularheparinCallimprovethefibrinolyticsystemandtheregulationofendothelialcellfunction.Itcanrescuepatientswithacutecoronarysyndromeanditworthtobeapplied7、clinically.【KeywordslAcutecoronarysyndrome;Fibrinolytiesystem;Endothelialceils;LowmolecularweightheparinFirst-author’Saddress:ThePeople’SHospitalofLonghuiCounty,Longhui422200,Chinadoi:10.3969/j.issn.1674-4985.2014.08.040冠心病是一类常见心血管疾病,近几年的发病率有所疗组男l6例,女l1例,年龄46—68岁,平均(55.62±8.17)岁,增加8、,并有年轻化的趋势,急性冠脉综合征(acutecor
3、ls/WANGXiao-jun.//MedicaiInnovationofChina.2014.11(08):092-093【Abstract】Objective:Toexploretheclinicaleffectonfibrinolyticsystemandendothelialfunctionoflowmolecularhepafinintreatmentoftheacutecoronarysyndrome.Method:Fifty—fourpatientswerechosentobetheACSgroupinthehospita1.TheACSgro
4、upwasrandomlydividedintotwogroups.Theobservationgroupandthenormalgroupbothh'ad27patients.Fifty—fourhealthypeoplewerechosentobethecontrolgroupduringthesametime.Thenormalgroupwastreatedwithanticoagulant,statinsandcalciumantagonists.Theobservationgroupwastreatedwithlowmolecularheparin
5、basedonthesametreatmentofthenormalgroup.TohadacomparisonbetweenthesethreegroupsofthetPA,PAI-tandvWF.Result:ThetPA,PAI—landthevWFoftheACSgroupweredifferentwiththecontrolgroup,andthediferencebetweenthetwogroupswereallstatisticallysignificant(P6、iongroupwerediferentwiththenormalgroup,andthediferencebetweenthetwogroupswereaIlstatisticallysignificant(P<0.05).Conclusion:LowmolecularheparinCallimprovethefibrinolyticsystemandtheregulationofendothelialcellfunction.Itcanrescuepatientswithacutecoronarysyndromeanditworthtobeapplied7、clinically.【KeywordslAcutecoronarysyndrome;Fibrinolytiesystem;Endothelialceils;LowmolecularweightheparinFirst-author’Saddress:ThePeople’SHospitalofLonghuiCounty,Longhui422200,Chinadoi:10.3969/j.issn.1674-4985.2014.08.040冠心病是一类常见心血管疾病,近几年的发病率有所疗组男l6例,女l1例,年龄46—68岁,平均(55.62±8.17)岁,增加8、,并有年轻化的趋势,急性冠脉综合征(acutecor
6、iongroupwerediferentwiththenormalgroup,andthediferencebetweenthetwogroupswereaIlstatisticallysignificant(P<0.05).Conclusion:LowmolecularheparinCallimprovethefibrinolyticsystemandtheregulationofendothelialcellfunction.Itcanrescuepatientswithacutecoronarysyndromeanditworthtobeapplied
7、clinically.【KeywordslAcutecoronarysyndrome;Fibrinolytiesystem;Endothelialceils;LowmolecularweightheparinFirst-author’Saddress:ThePeople’SHospitalofLonghuiCounty,Longhui422200,Chinadoi:10.3969/j.issn.1674-4985.2014.08.040冠心病是一类常见心血管疾病,近几年的发病率有所疗组男l6例,女l1例,年龄46—68岁,平均(55.62±8.17)岁,增加
8、,并有年轻化的趋势,急性冠脉综合征(acutecor
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