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时间:2020-05-07
《小剂量肝素佐治小儿支原体肺炎-论文.pdf》由会员上传分享,免费在线阅读,更多相关内容在应用文档-天天文库。
1、中华生物医学工程杂志2013年6月第19卷第3期ChinJBiomedEng,Jun—e—201QL—No—.3·243·新技术与临床小剂量肝素佐治小儿支原体肺炎褚静李晓云【摘要】目的探讨小剂量肝素佐治小儿支原体肺炎的疗效。方法收集2010年1月一2012年1月本科室住院治疗的支原体肺炎患儿84例,随机数字表法分为对照组42例,治疗组42例。对照组给予阿奇霉素静脉滴注及口服治疗,治疗组加用小剂量肝素静脉滴注。比较两组患儿热退时间、咳嗽及肺部哕音消失时间、住院时间及疗效。结果与对照组比较,治疗组患儿热退时间、咳嗽及肺部哕音消失时间、住院
2、时间均明显缩短[(5.93+0.79)d比(7.57~0.72)d,(7.10~0.91)d比(10.83-e1.08)d,(9.15±3.26)d比(11.52_+3.95)d,均P<0.05]。治疗组显效41例(97.6%),有效1例(2.4%);对照组显效35例(83.3%),有效7例(16.7%)。结论小剂量肝素辅佐治疗支原体肺炎疗效较好。【关键词1肝素;肺炎,支原体;支原体感染;儿童Low-dosehepafinintheadjuncttreatmentofchildrenwithmycoplasmalpneumoniaCH
3、Uring.LIXiao—yun.DepartmentofPediatrics,A~liated】,CentralHospital,WeifangMedicalCollege,ShangdongQingzhou262500,ChinaCorrespondingauthor:CHUring,Email:neuroman@163.corn【Abstract】ObjectiveToexploretheefficacyoflow.doseheparinintheadjuncttreatmentofchildrenwithmyeoplasmal
4、pneumonia.MethodsEighty—fourinpatientsinourdepartmentbetweenJanuary2010andJanuary2012wererecruitedandallocatedtocontrolgroup(n=42)andtreatmentgroup(n=42)byrandomnumbertable.Childrenincontrolgroupweretreatedwithintravenousandoralazithromycin,treatmentgroupreceivedadditio
5、nallow—doseheparinintravenousinjectionbasedoncontrolgroup.Thedurationofrecoveryfromfebrile,coughandcrackles,thelengthofhospitalstayandtheefficacyintwogroupswerecompared.ResultsComparedwithcontrolgroup,thetreatmentgrouppresentedsignificantlyshorterdurationofrecoveryfromf
6、ebrile,coughandcrackles,andthelengthofhospitalstayl(5.93_+0.79)dVS(7.57+0.72)d,(7.10-+0.91)dVS(10.83-+1。08)d,(9.15+_3.26)dVS(11.52_+3.95)d,allP<0.05].Thetreatmentgrouphadhigherexcellenteffectivenessrate(41/42,97.6%VS35/42,83I3%)yetlowereffectivenessrate(1/42,2.4%VS7/42,
7、16.7%)ascomparedtocontrolgroup.ConclusionLow—dosehepafinshouldberegardedasausefuladjuncttreatmentofchildrenwithmycoplasmalpneumonia.【Keywords】Hepa6n;Pneumonia,mycoplasma;Mycoplasmainfections;Child肺炎支原体(Mycoplasmapneumoniae)是人类支统,还可以引起肺外其他器官发生并发症。由于肝原体肺炎的病原体。支原体肺炎的病理改变以间
8、素可抑制补体系统及白细胞趋化性,中和多种致炎质性肺炎为主,常并发支气管肺炎,又称为原发性因子,降低内皮细胞的通透性,具有一定的抗炎作非典型性肺炎。近年来临床上支原体肺炎发病率用。我们在常规治疗支原体肺炎的同时加用小剂较高
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