加味三香汤治疗肝郁脾虚型功能性消化不良的临床观察-论文.pdf

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1、环球中医药2014年6月第7卷第6期GlobalTraditionalChineseMedicine，June2014，Vo1．7，No．6437·论著·加味三香汤治疗肝郁脾虚型功能性消化不良的临床观察许卫华王微吕冉符思【摘要】目的观察中药加味三香汤治疗肝郁脾虚型功能性消化不良的临床疗效以及对焦虑、抑郁状态的影响。方法本研究采用随机、对照方法研究，共收集81例患者，随机分为治疗组与对照组。治疗组给予中药加味三香汤治疗，对照组给予西药复方消化酶治疗，疗程28天，对患者治疗前后的症状积分、Zung焦虑自评量表(self-ratinganxietyscale，S

2、AS)、抑郁自评量表(self-ratingde—pressionscale，SDS)积分进行统计分析。结果14天有效率治疗组与对照组无显著性差异(66．7％与64．0％，P>0．05)；28天有效率治疗组显著高于对照组(88．2％与68．0％，P<0．05)；治疗组与对照组治疗28天后症状积分较治疗前均显著减少(P<0．05)，治疗前后症状积分、餐后饱胀积分、早饱积分下降程度治疗组与对照组比较有显著性差异(P<0．05)。焦虑、抑郁评分方面：治疗组治疗28天后SAS、SDS积分较治疗前均显著下降(P<0．05)；治疗组SAS、SDS积分下降程度显著高于对

3、照组(P<0．05)。安全性评价两组均无严重不良反应。结论加味三香汤治疗肝郁脾虚型功能性消化不良具有良好的疗效及安全性，并可改善患者焦虑、抑郁状态。【关键词】加味三香汤；功能性消化不良；肝郁脾虚证【中图分类号】R256．32【文献标识码】Adoi：10．3969／j．issn．1674．1749．2014．06．009ClinicalstudyofJiaweiSanxiangdecoctiontreatmentonpatientswithfunctionaldyspepsiaofliverstagnancyandspleendeficiencytypeXU

4、Wei—hua，WANGWei，LYURan，etal，TCMgastroenterologydepartmentofChina—JapanFriendshipHospital，Beng100029，ChinaCorrespondingauthor：FUsi，E—mail：fusibj57@aliyun．con【Abstract】Objectiveq'oexploretheeficacyofJiaweiSanxiangDecoctionandtheinfluenceonanxiousanddepressivestateofliverstagnancyand

5、spleendeficiencytypeoffunctionaldyspepsia(FD)．MethodsArandomizedcontrolledtrialswasconducted．81casesofFDpatientswererecruitedanddivid—edintotreatmentgroupandcontrolgroup．TreatmentgroupwastreatedwithJiaweiSanxiangDecoction，controlgroupwastreatedwithCompoundDigestiveEnzymeCapsulesfo

6、r28days．Thesymptomscore，self-ratinganxietyscale(SAS)，self-ratingdepressionscale(SDS)wereanalyzedbeforeandaftertreatment．ResultsTherewasnosignificantdifferencebetweentreatmentgroupandcontrolgroupf66．7％vs．64．0％)after14daysoftreatment(P>0．05)．However，therewassignificantdifferencebetw

7、eentreat-mentgroupandcontrolgroupafler28daysoftreatment(88．2％vs68．O％，P<0．05)．Thesymptomscoreinbothgroupsweresignificantlydecreasedafter28daysoftreatment(P<0．05)．Thesymptomscore，postprandialfullnessscore，earlysatietyscoreoftreatmentgroupweresignificantlydecreasedcon-paredtocontrolg

8、roup(P<0．05)after28daysoftreatmen