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时间:2020-05-07
《健脾补肾法对慢性乙型肝炎患者Th9/Treg平衡的影响及意义-论文.pdf》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、中西医结合肝病杂志2014年第24卷第1期·13·doi:10.3969/j.issn.1005-0264.2014.O1.004健脾补肾法对慢性乙型肝炎患者Th9/Treg平衡的影响及意义刘肄辉张永华刘莉周红娟冯慧浙江省中西医结合医院肝病科(浙江杭州,310003)摘要目的:观察健脾补肾法对慢性乙型肝炎(CHB)患者Th9/Treg平衡的影响及临床意义。方法:选择符合抗病毒指征的CHB患者100例,分为观察组及对照组,每组各5O例,观察组采用健脾补肾中药联合核苷(酸)类似物治疗,对照组仅用核苷(酸)类似物治疗,治疗前后测定Th9、Treg水平,疗程为24周。同时选择健康志愿者50例
2、,测定Th9、Treg水平。结果:慢性乙肝患者与健康对照组Th9、Treg、Th9/Treg比较差异均有统计学意义(P<0.05),观察组Th9、Treg、Th9/Treg治疗前后比较差异均有统计学意义(P<0.05),对照组Th9、Treg、Th9/Treg治疗前后比较差异均无统计学意义(P>0.05);观察组与对照组Th9、Treg、Th9/Treg治疗后比较差异均有统计学意义(P<0.05)。观察组AI复常率与对照组比较差异有统计学意义(P<0.05),观察组HBVDNA转阴率与对照组比较差异有统计学意义(P<0.05),观察组HBeAg转换率与对照组比较差异无统计学意义(P>
3、0.05)。结论:Th9/Treg在乙肝病毒感染患者中存在失衡,健脾补肾中药能通过调节Th9/Treg提高核苷(酸)类似物治疗CHB的疗效。关键词肝炎,乙型,慢性;Th9细胞;调节性T细胞;健脾补肾;核苷(酸)类似物InfluenceofChinesemedicinetherapyforstrengthening——Piandnourishing——ShenonTh9/TreginpatientswithchronichepatitisBtreatedbynucleo-·sideLIUYi—Hui,ZHANGYong—hua,LIULi,eta1.ZhejiangHospitalof
4、IntegratedTraditionalandWesternMedicine(HangzhouZhefiang,310003)ChinaAbstractObjective:TodiscusstheinfluenceofChinesemedicinetherapyforstrengthening—Piandnourishing—ShenonTh9/TreginpatientswithchronichepatitisBtreatedbynucleoside.Methods:OnehundredpatientswithchronichepatitisBweredividedintotwo
5、groups:observationgroupandcontrolgroup,eachgrouphad50patients.Th9andTregof100patientsand50heMthyvolunteersweredetected.Patientsinthecontrolgroupwereonlygiventonucleoside/nucleotide.Patientsintheobservationgroupweregiventonucleoside/nucleotideandtraditionalChinesedrug.Results:Th9andTregofpatient
6、swithhepa—tifsBvirusinfectionweresignificantlydifferentthanthoseofhealthyvolunteers(P<0.05).Beforeandaftertreatmentofob-servationgroup,therewerestatisticalsignificanceofTh9,Treg,Th9/Treg(P<0.05).ButthoseofcontrolgroupwerenotstatisticalsignificanceofTh9,Treg,Th9/Treg(P>0.05).Aftertreatmentoftwog
7、roupswerestatisticalsignificanceofTh9,Treg,Th9/Treg(P<0.05).ThenegativelyinversingrateofALTandHBVDNAofobservationgroupweresignificantlydif-ferentthanthoseofcontrolgroup(P<0.05).HBeAgdivertingrateofobservationgroupwerenotsignifican
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