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时间:2020-05-07
《HBV感染者精液HBV-DNA载量对子代垂直传播的影响-论文.pdf》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、中华流行病学杂~2014年2,H第35卷第2期ChinJEpidemiol,February2014,Vo1.35,No.2·117··现场调查·HBV感染者精液HBV-DNA载量对子代垂直传播的影响张荣莲王梅颖陈起燕任坤海修晓燕邱丽茵黄艳红【摘要】目的探讨HBV感染者精液HBV-DNA载量对子代垂直传播的影响。方法选择福建省妇幼保健院2009年8月至2011年11月初次产前检查孕妇(母)血清HBsAg阴性、丈夫(父)血清HBsAg阳性的138个家庭及其新生儿为研究对象。知情同意下收集孕妇血液、其夫血液和精液及分娩时新生儿脐带血,检
2、测HBV血清学标志物(HBVM)、HBV-DNA。以脐带血HBV-DNA载量/>5×10copies/ml为病例组,脐带血HBV-DNA载量<5×10copies/ml为对照组。结果(1)新生儿脐带血HBV-DNA阳性率为34.8%(48/138)、HBsAg阳性率为28.3%(39/138),HBeAg阳性率为15.2%(21/138)。(2)父血清HBV-DNA阳性率为76.8%(106/138)、HBeAg阳性率为42.8%(59/138);精液HBV-DNA阳性率为21.0%(29/138)。(3)单因素分析显示,父血清HB
3、V-DNA阳性、父血清HBeAg阳性、精液HBV-DNA阳性、父对乙型肝炎(乙肝)传播途径及预防方法、乙肝一级家族史为HBV垂直传播的危险因素(P4、精液HBV-DNA载量为10copies/ml其预测的敏感度和特异度较高,是预测发生HBV垂直传播的分界点。结论父血清HBV-DNA阳性、父HBeAg阳性、精液HBV-DNA阳性是HBV父婴垂直传播的危险因素;父血清HBV-DNA载量>10copies/ml、精液HBV-DNA载量>10copies/ml时,增加父婴HBV垂直传播的阳性率。【关键词】乙型肝炎病毒;垂直传播;病毒载量;精液;血液StudyontherelationshipbetweensemenHBV.DNAloadandofspring—paternal—verti5、cal—transmissionofHBVZhangRonglian,WangMeiying,ChenQiyan,RenKunhai,XiuXiaoyan,OiuLiyin,HuangYanhong.1FuiianProvincialMaternityandChildHealthHospitaZ,Fuzhou350001,China;2OuanzhouWomen’sandChildren’sHospitalCorrespondingauthor:ChenQiyan,Email:534086942@qq.comThisworkwass6、upportedbygrantsfromtheFuiianProvincialNaturalScienceFoundation(No.2011J01124)andtheFuiianPr0vincialMedicalInnovationofChina(No.2011一CXB一17).【Abstract】0bjectiveToexploretherelationshipbetweenHBV—DNAloadandtheofspringverticaltransmissionOfHBVMethods138familieswhohadtake7、ntheexaminationbetweenAugust2009andNovember2011buttheHBsAgofthehousewifewasnegative。werechosenasresearchobjects.Bloodfromthecouplesandspermsfromthehusbandsduringpregnancywerefollowedandcollectedfordetectiononrelatedindicators.CordbloodwassampledafterdeliveryforHBVMandH8、BV_DNAquantification.ThosewithHBV-DNA1oad≥5×10copies/m1werechosenascaseswhilethose<5×10copies/mlwereformedascontrols.
4、精液HBV-DNA载量为10copies/ml其预测的敏感度和特异度较高,是预测发生HBV垂直传播的分界点。结论父血清HBV-DNA阳性、父HBeAg阳性、精液HBV-DNA阳性是HBV父婴垂直传播的危险因素;父血清HBV-DNA载量>10copies/ml、精液HBV-DNA载量>10copies/ml时,增加父婴HBV垂直传播的阳性率。【关键词】乙型肝炎病毒;垂直传播;病毒载量;精液;血液StudyontherelationshipbetweensemenHBV.DNAloadandofspring—paternal—verti
5、cal—transmissionofHBVZhangRonglian,WangMeiying,ChenQiyan,RenKunhai,XiuXiaoyan,OiuLiyin,HuangYanhong.1FuiianProvincialMaternityandChildHealthHospitaZ,Fuzhou350001,China;2OuanzhouWomen’sandChildren’sHospitalCorrespondingauthor:ChenQiyan,Email:534086942@qq.comThisworkwass
6、upportedbygrantsfromtheFuiianProvincialNaturalScienceFoundation(No.2011J01124)andtheFuiianPr0vincialMedicalInnovationofChina(No.2011一CXB一17).【Abstract】0bjectiveToexploretherelationshipbetweenHBV—DNAloadandtheofspringverticaltransmissionOfHBVMethods138familieswhohadtake
7、ntheexaminationbetweenAugust2009andNovember2011buttheHBsAgofthehousewifewasnegative。werechosenasresearchobjects.Bloodfromthecouplesandspermsfromthehusbandsduringpregnancywerefollowedandcollectedfordetectiononrelatedindicators.CordbloodwassampledafterdeliveryforHBVMandH
8、BV_DNAquantification.ThosewithHBV-DNA1oad≥5×10copies/m1werechosenascaseswhilethose<5×10copies/mlwereformedascontrols.
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