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时间:2020-05-04
《不同妊娠期振动对SD大鼠子代空间学习记忆的影响-论文.pdf》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、938中国儿童保健杂志2014年O9月第22卷第9期CJCHCSEPT.2014,Vol22,No.9·基础科研论著·不同妊娠期振动对SD大鼠子代空间学习记忆的影响赵萍,杨柳,陈超,曾晓雯,张玲,冼丹霞,金宇中山大学公共卫生学院妇幼卫生学系,广东广州510080摘要:目的探讨不同妊娠期振动对大鼠子代空间学习记忆的影响。方法分别在SD大鼠妊娠的1~7d、8~14d、15~21d施加强弱交替的振动刺激,在子鼠60d使用Barnes迷宫测试其空间学习记忆能力,比较各组间空间学习记忆的差异。结果学习过程:1)探索路程:妊娠早期振动组在第4天,妊娠中期在第1天,妊娠晚期在第1天高于对照组,妊娠晚期在第
2、2、3天低于对照组(P3、)和错误探索时间(Mann—WhitneyU一164.5O)明显低于对照组(P<0.05或4、ZHAOPing,rANGLiu,CHENChao,ZENGXiao—we~'l,ZHANGLing,XIANDan-xia,JINYu.(PublicHealthSchoolofSunYat-senUniversity,Guangzhou,Guangdong510080,China)Correspondingauthor:JINYu,E-mail:jinyu@mail.sysu.edu.cTlAbstract:ObjectiveToexploretheeffectsofprenatalvibrationstressindifferentgestationaltimepointsonthes5、pa—tiallearningandmemoryinrats.MethodsTheSprague—Dawley(SD)pregnantratswerevibratedstrongandweakalter—natelyin1~7d,8~14d,15~21dofgestationperiod,andtheoffspringwastestedinBarnesmazetoidentifytheirspatiallearningandmemory,thedifferenceofeachgroupthencompared.ResultsLearningprocess:1)Thejourneyofexpl6、ora—tion:Itwashigherthancontrolgroupduringearlypregnancygroupwasin4d,duringmiddlepregnancygroupinldandduringlatepregnancygroupinld:Itwaslowerthancontrolgroupduringlatepregnancygroupin2and3d(P7、eg—nancygroupin1dand2d。duringlatepregnancygroupin1,2,3,7,8d(P
3、)和错误探索时间(Mann—WhitneyU一164.5O)明显低于对照组(P<0.05或4、ZHAOPing,rANGLiu,CHENChao,ZENGXiao—we~'l,ZHANGLing,XIANDan-xia,JINYu.(PublicHealthSchoolofSunYat-senUniversity,Guangzhou,Guangdong510080,China)Correspondingauthor:JINYu,E-mail:jinyu@mail.sysu.edu.cTlAbstract:ObjectiveToexploretheeffectsofprenatalvibrationstressindifferentgestationaltimepointsonthes5、pa—tiallearningandmemoryinrats.MethodsTheSprague—Dawley(SD)pregnantratswerevibratedstrongandweakalter—natelyin1~7d,8~14d,15~21dofgestationperiod,andtheoffspringwastestedinBarnesmazetoidentifytheirspatiallearningandmemory,thedifferenceofeachgroupthencompared.ResultsLearningprocess:1)Thejourneyofexpl6、ora—tion:Itwashigherthancontrolgroupduringearlypregnancygroupwasin4d,duringmiddlepregnancygroupinldandduringlatepregnancygroupinld:Itwaslowerthancontrolgroupduringlatepregnancygroupin2and3d(P7、eg—nancygroupin1dand2d。duringlatepregnancygroupin1,2,3,7,8d(P
4、ZHAOPing,rANGLiu,CHENChao,ZENGXiao—we~'l,ZHANGLing,XIANDan-xia,JINYu.(PublicHealthSchoolofSunYat-senUniversity,Guangzhou,Guangdong510080,China)Correspondingauthor:JINYu,E-mail:jinyu@mail.sysu.edu.cTlAbstract:ObjectiveToexploretheeffectsofprenatalvibrationstressindifferentgestationaltimepointsonthes
5、pa—tiallearningandmemoryinrats.MethodsTheSprague—Dawley(SD)pregnantratswerevibratedstrongandweakalter—natelyin1~7d,8~14d,15~21dofgestationperiod,andtheoffspringwastestedinBarnesmazetoidentifytheirspatiallearningandmemory,thedifferenceofeachgroupthencompared.ResultsLearningprocess:1)Thejourneyofexpl
6、ora—tion:Itwashigherthancontrolgroupduringearlypregnancygroupwasin4d,duringmiddlepregnancygroupinldandduringlatepregnancygroupinld:Itwaslowerthancontrolgroupduringlatepregnancygroupin2and3d(P7、eg—nancygroupin1dand2d。duringlatepregnancygroupin1,2,3,7,8d(P
7、eg—nancygroupin1dand2d。duringlatepregnancygroupin1,2,3,7,8d(P
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