实时超声弹性成像评价肝脏射频消融灶的价值-论文.pdf

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1、·l76·中国临床医学影像杂志2014年第25卷第3期JChinClinMedImaging，2014，Vo1．25，No．3实时超声弹性成像评价肝脏射频消融灶的价值彭金波，杨红，何云，覃肖溪(广西医科大学第一附属医院超声科，广西南宁530021)【摘要1目的：利用实时超声弹性成像(Real—timeelastography，RTE)观察离体及活体肝脏射频消融(Radiofrequencyabla．tion，RFA)术后消融灶的弹性变化，探讨RTE评估RFA消融范围的价值。方法：离体实验选取新鲜离体猪肝5个，活体实验选取新西兰大

2、白兔2O只。在超声引导下将射频针置于猪肝及兔肝内进行消融，分别得到消融灶20个。RFA结束后采用RTE观察消融灶，测量消融灶最大切面的左右径及前后径并计算面积，与大体标本测量值进行比较。结果：消融结束后RTE图像显示离体猪肝及活体兔肝消融灶呈均匀蓝色．与周围组织分界清楚。Pearson相关分析显示离体猪肝RFA术后RTE测量消融灶面积与大体标本测量结果呈显著相关(r=0．91，P<0．05)。Spearman相关分析显示活体兔肝RFA术后RTE测量消融灶面积与大体标本测量结果亦具有较好的相关性(r=0．49，P<0．05)。结论

3、：RTE可清晰显示肝脏RFA灶的范围，有望成为评价RFA的有效方法。【关键词】肝；兔；猪；导管消融术；超声检查【中图分类号】R333．4；R445．1【文献标识码】A[文章编号】1008—1062(2014)03—0176—03Thevalueofreal-timeelastographyinevaluatingtheefectofradiofrequeneyablativetreatmentinliverlesions：anexperimentalstudyPENGJin-bo，YANGHong,HEYun，QmXiao-xi

4、(DepartmentofMedicalUltrasonics，FirstAffiliatedHospital,GuangxiMedicalUniversity,Nanning530021，China)Abstract：Objective：Toinvestigatetheelasticitychangeofablativelesionsresultingfromradiofrequencyablation(RFA)invitroliverandinvivoliverbyreal-timeelastography(RTE)，eva

5、luateRTEindepictingcircumscriptionofablativelesions．MaterialsandMethods：Fiveinvitroporcineliversandtwentyrabbitsliverswerechosenforthisstudy．Twentyablativele—sionswereobtainedusingRFAunderultrasoundguidanceineachexperiment．AfterRFA，RTEwasperformed．Themaximumve~icaldi

6、ameterandtransversediameterofablativelesionsweretakenonRTEimageandcomparedwiththemeasurementsobtainedfrompathologicexamination．Results：HomogeneousblueanddistinctcircumscriptionfromlivertissuewasshowedonRTEimageofallablativelesionsperformedRFAinexperiments．Pearsoncorr

7、elationanalysisdemonstratedthattheareaofablativelesionsmeasuredonRTEimageperformedafterRFAcorrelatedwellwiththemeasurementonmacropathologyspeci—men(r=0．91，P<0．05)invitroliverexperment．AndSpearmancorelationanalysisdemonstratedthattheareaofablativelesionsmeasuredonRTEi

8、mageperformedafterRFAcorrelatedwellwiththemeasurementonmacropathologycorrelatedfr=0．49．P<0．051invivoliverexperment．Conclusions：RTEm