京尼平苷对雷公藤甲素肝损伤的保护作用-论文.pdf

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1、中药药理与临床2014；30(3)6913LeoneTC，KellyDP．Transcriptionalcontrolofcardiacfuelmetabo-heartfailure．JMolCellCardiol，2011；51(4)：578—583lismandmitochondrialfunction．ColdSpringHarbSympQaantBiol，2011；16SihagS，CresciS，LiAY，eta1．PGC-laandERRatargetgenedown—76：175—182regulationisasignatu

2、reofthefailinghumanheart．MolCellCardiol，2009；4614SchillingJ，IJaiL，SambandamN，eta1．Toll—likereceptor-mediated(3)：201—212inflammatorysignaling~pmgremscardiacenergymetabolismbyrepressing17VegaRB，HussJM，KellyDP．ThecoactivatorPGC-Icooperateswithperoxisomeprolifamtor-activatedre

3、ceptor．ycoactivator一1signaling．Circula-pemxi~meprolifcmtor-activatedreceptoraintranscriptionalcontrolofnuclc-tion：HeartFailure，2011；4(4)：474—482argenesencodingmitoehondrialfattyacidoxidationenzymes．Molecularand15SchillingJ，KellyDP．ThePGC·1CascadeasatherapeutictargetforCell

4、ularBiology，200o；20(5)：1868—1876EfectofastragalosideIVonmyocardialhypertrophyandPGC-lainducedbyisoproterenolinratsZhangSuping，LuanAina，LuMeili，HanRonghui，HuJin，WangHongxin(KeyLaboratoryofCardiovascularandCerebrovaseularDrugResearchofLiaoningProvince，DrugResearchInstitute，L

5、iaoningMedicalCollege，Jinzhou121001)Objective：ToexploretheefectofofAstragalosideIVonmyocardialhypertrophyandPGC-lotinratsinducedbyisopmterenol(ISO)．Methods：MaleSprague-Dauley(SD)ratsweretreatedwithastragalosidesandpropranololbyintragastric(ig)administrationrespectively，ata

6、doseof20，40，80ms／ks／dayand40ms／kg／dayonedaypriortoisoproterenolorvehicle(5mg／kg／day，sc)for2week．Attheendofthetreatmentperiod，HMI，LVMIandpathologicalsectionbyHEstainingwereobserved．ATP，ADP，AMPandFFAlevelsweredetectedbyElisa；TheexpressionofANPmRNAweredeterminedbyRT．PCR；Theex

7、pressionofPGC．1etwereassessedbyWesternblotResults：ISO．modelgroupmarkedlyelevatedtheleftventricleweight(LVw)／bodyweight(BW)，heartweight(HW)／bodyweight(BW)ratioandANPmRNAleve1．ComparedwithISOgroup，treatmentwithASIV(4o，80ms／kg／d)significantlyimprovedATP／AMP，ATP／ADPratioandPGC

8、-lotproteinexpressionandreducedtheaculationoffreefattyacid．Conclusions：ASIVmayalleviateme