声辐射力脉冲成像技术检测大鼠非酒精性脂肪肝剪切波速率与胰岛素抵抗的相关性-论文.pdf

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1、中国医学影像技术2013年第29卷第12期ChinJMedImagingTechnol，2013，Vol29，No12·1913·◆：◆实验研究AcousticradiationforceimpulseinevaluationoncorrelationofshearwavevelocityoftheliverwithinsulinresistanceinratmodelsofnonalcoholicfattyliverdiseaseLINNing，TANGLi，LIJian—wei，DINGGui—sheng，FANGZhi

2、—hua(DepartmentofUltrasound，ProvincialClinicalMedicalCollegeofFujianMedicalUniversity，FujianProvincialHospital，Fuzhou350001，China)[Abstract]ObjectiveToexplorecorrelationofshearwavevelocity(SWV)oftheliverwithinsulinresistanee(IR)inratmodelsofnonalcoholicfatty1iverdi

3、sease(NAFLD)withacousticradiationforceimpulse(ARFI)．MethodsTotallymale32SDratswererandomlydividedintocontrolgroup(一16)andmodelgroup(一16)．Thelevelsofserumalaninetrans—aminase(ALT)，aspartatcaminotransferase(AST)，triglyceride(TG)，totalcholesterol(TC)，fastbloodglucose(

4、FBG)andfastinsulin(FINS)inratsweremeasured．Thenhomeostasismode1assessmentofinsulinresistance(H0MA一1R)andinsulinsensitivityindex(ISI)werecalculated．ARF1wasperformedtoobtainSWVoftheliver，andthecorrelationofSWVwithaboveindexeswasanalyzed．Thepathologicalchangesoftheliv

5、erwereobserved．ResultsThelevelsofserumALT，AST，TG，TC，FBGandFINSweresignificantlyhigherinmodelgroupthanthoseincontrolgroup(allP<0．05)withtime-dependence(allP<0．05)．HOMA-IRinmodelgroupwassignificantlyhigherandIS1wassignificantlylowerthanthatincontrolgroup(bothP<0．05)．

6、SWVinmodelgroupwassignificantlyhigherthanthatincontrolgroup(bothP<0．01)withtime—dependence(P

7、VofliveassessedwithARFI．[-Keywords]Fattyliver，non-alcoholic；Insulinresistance；Acousticradiationforceimpulseimaging；Models，animal声辐射力脉冲成像技术检测大鼠非酒精性脂肪肝剪切波速率与胰岛素抵抗的相关性林宁，唐力，李建卫，丁桂升，范志华(福建医科大学省立临床医学院福建省立医院超声科，福建福卅l350001)[摘要]目的采用声辐射力脉冲(ARFI)成像技术检测大鼠非酒精性脂肪肝(NAFLD)肝脏剪切波速

8、率(SWV)与胰岛素抵抗(IR)的相关性。方法将32只雄性SD大鼠随机分为正常组(16只)与模型组(16只)，检测大鼠血清丙氨酸氨基转移酶(ALT)、天门冬氨基酸氨基转移酶(AST)、甘油三酯(TG)、总胆固醇(TC)、空腹血糖(FBG)及空腹胰岛素(FINs)水平，计算稳态模型胰岛素抵抗