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《右美托咪定复合丙泊酚用于开胸手术患者麻醉的临床观察.pdf》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、·30·医药论坛杂志2014年1月第35卷第1期JMedicalForumVo1.35No.1Janua~2014右美托咪定复合丙泊酚用于开胸手术患者麻醉的临床观察章-X--~1,2,张海风,卢锡华,冯艳平,乔海灵1.郑州大学临床药理研究所,郑州450052;2.郑州大学附属肿瘤医院麻醉科摘要:目的在开胸手术中,以丙泊酚为基础的全凭静脉麻醉,全程复合使用右美托咪定(DEX),探讨其对丙泊酚用量、血流动力学和睁眼时间等指标的影响。方法60例患者随机分为对照组(C组)和DEX组(D组),每组30例。D组于麻醉诱导前泵入DEX负荷剂量0.6g/kg,继以0.2txg/(kg·h)持续泵注至手术结
2、束前30min;C组以同样方式输注生理盐水。分别记录两组患者各时点平均动脉压,以及术中丙泊酚用量、睁眼时间和躁动评分等。结果D组在T3~T6各时点MAP和HR变化幅度较C组小,差别具有显著性(P<0.05),D患者组舒芬太尼和丙泊酚用量明显少于C组(P<0.05),两组患者顺啊曲库铵用量和睁眼时间差异无统计学意义,D组躁动评分明显低于C组(P<0.05)。结论DEX辅助全麻用于开胸手术患者,减少舒芬太尼和丙}白酚用量,血压更平稳,并降低苏醒期躁动的发生。关键词:右美托咪定;丙泊酚;开胸手术;血流动力学中图分类号:R614.2文献标识码:B文章编号:1672—3422(2014)叭-0030
3、-03Clinical0bservati0n0fAnesthesiawithDexmedetomidinecombinedwithPropofolinpatientundergoingthoracicsurgery、ZHANGYun—i,ZHANGHai—feng,LUXi—hua,FENGYan—ping,QIAOHai—lingDepartmentofAneasthesiology,Affiliatedtumorhospital,ZhengZhouUniversity,Zhengzhou450008,ChinaAbstract:ObjectiveToobservetheeffectof
4、anesthesiawithdexmedetomidinecombinedwithpropo~linpatientunder—goingthoracicsurgery.MethodsTotally60selectivethoracicsurgerypatientswererandomlydividedintocontrolgroup(groupC)andDEXgroup(groupD),30patientsineachgroup.PatientsingroupDreceivedintravenousinjectionofDEX(0.61xg/kg)15minbeforeinduction,
5、followedbyacontinuousinfusionatarateof0.2g/(kg·h)until30minbeforetheendofsurgery.GroupCreceivedavolume-matchedbolusandinfusionofplacebo(0.9%saline).HRandMAPwererecordedbeforeinfusiondrug(TO),beforeinduction(T1),beforeintubation(T2),afterintubation(T3),atthetimeofopenthoraces(T4),attheendofsurgery(
6、T5)andafterextubation(T6).Theamountofsufentanil,cisatracuriumandpropofolconsumed,eye—openingtime,andrestlessnessduringrecoverywererecorded.ResultsHRandMAPingroupCatT3~T6weresignificantlyincreasedcomparedwithgroupD(P<0.05).Theamountofsufentanilandpropo—f0lingroupDissignificantlydecreasedcomparedwit
7、hgroupC.Therewasnosignificantdifferenceineye—openingtimebetween,twogroups(P>0.05).ComparewithgroupC,restlessnessscoreweresignificantlydecreasedingroupD(P<0.05).ConclusionDEXasansystemicanestheticadjunctinthoracic
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