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时间:2020-05-02
《四君子汤联合缺血预处理对肝脏缺血再灌注损伤大鼠炎症因子及氧化应激的影响.pdf》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、浙江中西医结合杂志2014年第24卷第5期ZhejiangJITCWM(Vo1.24No.52014)387四君子汤联合缺血预处理对肝脏缺血再灌注损伤大鼠炎症因子及氧化应激的影响华晨傅天啸傅永清周剑兰菲任大为浙江中医药大学附属第一医院杭州310006摘要目的观察四君子汤联合缺血预处理(IPC)对肝脏缺血再灌注损伤大鼠炎症因子及氧化应激的影响。方法80只SD大鼠随机分成空白对照组、四君子汤预处理组、IPC组和四君子汤顸处理+IPC组,每组20只。肝脏缺血再灌注术后检测白细胞计数(WBC)、血小板计数(PLT);血清天门冬氨酸氨基转移酶(AST)谷氨酸氨基转移酶(AL
2、T);血清肿瘤坏死因子oL(TNF一0【)、白介素6(IL一6),以及肝组织中丙二醛(MDA)和超氧化物歧化酶(SOD)水平。结果四君子汤预处~+IPC组WBC、ALT及AST水平显著低于其余三组(P<0.05)。四君子汤预处理组与IPC组的ALT、AST水平较空白对照组显著降低(P<0.05)。四君子汤预处理+IPC组TNF—Ot水平显著低于其余三组(Jp<0.05)。三个实验组IL一6、MDA水平显著低于空白对照组(P3、论四君子汤联合IPC可减轻大鼠肝脏缺血再灌注过氧化损伤,抑制炎症因子,保护肝功能。关键词大鼠;肝脏缺血再灌注损伤;四君子汤;缺血预处理;肿瘤坏死因子仅;白介素6;丙二醛;超氧化物歧化酶EfectofSijunziDecoctionCombinedwithIschemiaPreconditioningonInflammatoryMediatorsandOx-idativeStressinRatswithHepaticIschemia/ReperfusionInjuryHUAChen,FUTianxiao,FUYongqing,ZHOUJian,eta1.Depart4、mentofSurgery,FirstHospitalAfiliatedtoZhejiangTraditionalMedicalUniversity,Hangzhou~10006),ChinaABSTRACTObjectiveToinvestigatetheeffectofSijunzidecoctionandischemiapreconditioning(IPC)onin—flammatorymediatorsandoxidativestressinratswithhepaticischemia-repefusion.MethodsEightySDratswer5、erandomlydividedintoSHAM,Sijunzidecoction,IPC,andSijunzidecoction+IPCgroups(n=20ineachgroup).Afterhepaticischemia—reperfusion,thelevelsofwhitebloodcellcount(WBC),platelet,alallineaminotransferase(ALT),aspartateaminotransferase(AST),tumornecrosisfactor—alpha(TNF-c~),interleukin-6(IL-6)6、,andmalondialdehyde(MDA)andsuperoxidedismutase(SOD)weremeasured.ResultsThelevelsofWBC,ALTandASTinSijunzidecoction+IPCgroupwassignificantlylowerthanthoseinother3groups(P<0.05).ThelevelsofAIJTandASTinSijunzidecoctionandIPCgroupsweresignificantlylowerthanthoseinshamgroup(P<0.05).Thelevel7、ofTNF—cdnSijunzidecoction+IPCgroupwassignificantlylowerthanthatinother3groups(P<0.05).Comparedwithother3groups.thelevelsofIL一6andMDAinshamgroupwassignificantlyhigherandSODwassignificantlylower(Ps<0.05).ThelevelofSODinSijunzidecoction+IPCgroupwassignificantlyhigherthanthatinSijunzideco8、ction
3、论四君子汤联合IPC可减轻大鼠肝脏缺血再灌注过氧化损伤,抑制炎症因子,保护肝功能。关键词大鼠;肝脏缺血再灌注损伤;四君子汤;缺血预处理;肿瘤坏死因子仅;白介素6;丙二醛;超氧化物歧化酶EfectofSijunziDecoctionCombinedwithIschemiaPreconditioningonInflammatoryMediatorsandOx-idativeStressinRatswithHepaticIschemia/ReperfusionInjuryHUAChen,FUTianxiao,FUYongqing,ZHOUJian,eta1.Depart
4、mentofSurgery,FirstHospitalAfiliatedtoZhejiangTraditionalMedicalUniversity,Hangzhou~10006),ChinaABSTRACTObjectiveToinvestigatetheeffectofSijunzidecoctionandischemiapreconditioning(IPC)onin—flammatorymediatorsandoxidativestressinratswithhepaticischemia-repefusion.MethodsEightySDratswer
5、erandomlydividedintoSHAM,Sijunzidecoction,IPC,andSijunzidecoction+IPCgroups(n=20ineachgroup).Afterhepaticischemia—reperfusion,thelevelsofwhitebloodcellcount(WBC),platelet,alallineaminotransferase(ALT),aspartateaminotransferase(AST),tumornecrosisfactor—alpha(TNF-c~),interleukin-6(IL-6)
6、,andmalondialdehyde(MDA)andsuperoxidedismutase(SOD)weremeasured.ResultsThelevelsofWBC,ALTandASTinSijunzidecoction+IPCgroupwassignificantlylowerthanthoseinother3groups(P<0.05).ThelevelsofAIJTandASTinSijunzidecoctionandIPCgroupsweresignificantlylowerthanthoseinshamgroup(P<0.05).Thelevel
7、ofTNF—cdnSijunzidecoction+IPCgroupwassignificantlylowerthanthatinother3groups(P<0.05).Comparedwithother3groups.thelevelsofIL一6andMDAinshamgroupwassignificantlyhigherandSODwassignificantlylower(Ps<0.05).ThelevelofSODinSijunzidecoction+IPCgroupwassignificantlyhigherthanthatinSijunzideco
8、ction
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