加味四妙勇安汤联合前列腺素E1治疗下肢动脉硬化闭塞症的临床疗效.pdf

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1、髓饵琢学杂志，2014，24(2)：42—45⑥2014CHINESEJOURNALOFMICROCIRCULATIONdoi：10．3969／j．issn．1OO5—1740．2014．02．011加味四妙勇安汤联合前列腺素E1治疗下肢动脉硬化闭塞症的临床疗效庄丽华胡家才*吴昊[中图分类号]R543．5[文献标识码]A[文章编号]1005—1740(2014)02—0042—04目的：观察加昧四妙勇安汤联合前列腺素El治疗下肢动脉硬化闭塞症(ASO)的临床疗效。方法：120例双侧下肢ASO患者，以分层随机法分为两组，每组各6O例。对照组用前列腺素E

2、120gg静脉滴注，1次／天；治疗组在对照组治疗基础上，另口服加味四妙勇安汤，1剂／天，早晚各1次。3O天为1个疗程，共4个疗程。观察两组的临床疗效，并测定治疗前后白介素一17A(IL一17A)、全血表观黏度、血浆黏度、血浆纤维蛋白原(FIB)水平变化。结果：治疗组治疗后总有效率优于对照组(96．67VS68．33，P<0．05)。两组治疗后IL一17A、全血表观黏度、血浆黏度和FIB水平(除对照组外)与治疗前比较，均有显著下降(P

3、降低炎性反应，改善患者血液流变性。关键词：动脉硬化闭塞症加味四妙勇安汤前列腺素E1临床疗效ClinicalEffectsofJiaWeiSiMiaoYongAnDecoctionCombinedwithPr0staandinE1inTreatingLowerLimbAtherosclerosisObliteransZHUANGLihua，HUjacai，WUHaoDepartentofTraditionalChineseMedicine，RenminHospitalofWuhanUniversity。Wuhan430060，China；Corress

4、pondingauthorobjective：ToobservetheclinicaleffectsofJiaweisimiaoyongandecoctioncombinedwithprostaglandinE1intreatinglowerlimbarteriosclerosisobliterans．Method：120casesofbilaterallowerlimbarteriosclerosisobiiteransweredividedintotwogroups(60caseseach)bystratifiedrandommethod．Pat

5、ientsinbothgroupsweregiven20gprostaglandinE1tOintravenousdrip，onceaday．Inaddition，PatientsintreatmentgroupweregivenJiaweisimiaoyongandecoction，whichwasoneagentadayandbetakentwiceinthemorningandevening．Thetreatmentwas30daysacourse，and4coursesintota1．Thenweobservedtheclinicaleffe

6、ctsandmeasuredinterleukinl7A(II一17A)，apparentviscosityofwholeblood，plasmaviscosity，fibrinogen(FIB)levelchangesbeforeandaftertreatment．Re‘suits：Thetotaleffectiverateofthetreatmentgroupwas96．67％comparedwith68．33％ofthecontrolgroup(P<0．05)；thelevelsofIL一17A，apparentviscosityofwhole

7、blood，plasmaviscosityandFIB(exceptthecontrolgroup)aftertreatmentinthetwogroupsweresignificantlylowerthanbeforethetreatment(P<0．05)；andtheleveloftreatmentgroupwerelowerthanthatofthecontrolgroup(P

8、landinE1inthetreatmentoflowerlimbarteriosclerosisoblit