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页数:5页
时间:2017-12-10
《全身联合鼓膜置管鼓室给予地塞米松治疗重度特发性突聋的疗效分析》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、第44卷第3期第339页华中科技大学学报(医学版)V01.44No.3P.3392015年6月ActaMedUnivSciTechnolHuazhongJun.2O15全身联合鼓膜置管鼓室给予地塞米松治疗重度特发性突聋的疗效分析郑烨贤,彭利艳,崔永华,刘爱国△华中科技大学同济医学院附属同济医院耳鼻咽喉一头颈外科,武汉430030摘要:目的分析鼓膜置管后鼓室给予地塞米松联合全身激素治疗重度特发性突聋的效果和影响其预后的因素。方法回顾性分析49例重度特发性突聋患者临床资料。49例重度特发性突聋患者依治疗方式分为2组:A组,29例,接受全身激素治疗;B组,2o例,接受鼓膜置管鼓室
2、给予地塞米松联合全身激素治疗。两组在发病年龄、性别、患耳、伴随耳鸣或眩晕症状等均经良好配对。比较两种治疗方法的疗效,并分析伴随耳鸣和眩晕症。状对预后的影响。结果A组治疗总有效率为69.0(20/29),痊愈率为6.9(2/29),B组总有效率为70.0(14/20),痊愈率为15.0(3/20),两组总有效率经卡方检验差异无统计学意义(P一0.938)。耳鸣或眩晕症状对治疗效果没有显著影响(均P>0.05)。治疗后各频率平均听阈改善经ANOVA分析显示,差异亦无统计学意义。结论在重度特发性突聋患者的治疗中,全身联合鼓膜置管鼓室给予地塞米松治疗与单纯全身给药的疗效相比没有明显
3、差异。耳鸣或眩晕等伴随症状对重度特发性突聋患者的预后无明显影响。关键词:鼓膜置管;鼓室给药;糖皮质激素;特发性突聋中图分类号:R764.437DOI:10.3870/j.issn.1672—0741_2O15.03.022EfficacyofCombinationTherapywithIntratympanicandSystemicDexamthasoneforTreatmentofPatientswithSevere-to-ProfoundIdiopathicSuddenSens0rineuralHearingLossZhengYexian,PengLiyan,CuiYo
4、nghuaetalDepartmentofOtorhinolaryngologyHeadandNeckSurgery,TongJiHospital,TongJiMedicalCollege,HuazhongUniversityofScienceandTechnology,Wuhan430030,ChinaAbstractObjectiveToexaminethetherapeuticefficacyofcombinationtherapywithintratympanicandsystemicdexamthasoneforthetreatmentofpatientswith
5、severe—to—profoundidiopathicsuddensensorineura1hearinglOSS(ISSNHL)andtheprognosticfactorsofthisdisease.MethodsClinicaldataof49severe—to—profoundpatientswithISSNHLwereretrospectivelyanalyzed.Thesepatientsweredividedintotwogroupsintermsofdifferenttherapeuticstrategies:groupA,inwhich29patient
6、sreceivedthesystemichigh-dosedexamethasonetaperingtherapy;groupB,inwhich,20patientsweregivennotonlysystemichigh—dosedexamesthasonetaperingtherapybutalsothetrans—tympanicdexamethasonetherapy.Patientsinbothgroupswerewellmatchedforage,sex,affectedpart,initialpuretoneaverage(PTA),dizziness,and
7、tinnitus.Thecurativeeffectwascomparedbetweenthetwogroupsandtheinfluenceofaccompanyingtinnitusanddizzinesswasanalyzedonprognosis.ResultsThetotaleffectiveratewas69.0(20/29)ingroupAand70.0(14/20)ingroupB.Therecoveryratewas6.9(2/29)ingroupAand15.0%(3/20)ingroupB.C
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