资源描述：
《~(99)tc~m-奥曲肽眼眶显像在甲状腺相关眼病中的临床应用》由会员上传分享，免费在线阅读，更多相关内容在行业资料-天天文库。
1、·1068·中华眼科杂志2006年12月第42卷第12期ChinJOphthalmol,December2006,Vol42,No112·论著·99mTc2奥曲肽眼眶显像在甲状腺相关眼病中的临床应用段炼李险峰陆克义张承刚胡光刘建中李思进99m【摘要】目的研究Tc2奥曲肽眼眶显像在判断甲状腺相关眼病(TAO)患者眼部炎性反应活动度中的临床价值。方法根据临床活动度评分(CAS)标准,将30例TAO患者分为活动组和非活99m动组,11例正常志愿者为对照组。所有对象行Tc2奥曲肽眼眶断层显像,并计算眼眶奥曲肽摄取
2、比值(UR)。6例活动组患者于抗炎治疗后进行了二次显像。结果3组眼眶的奥曲肽UR均数分别为1140±0118、1115±0110及1107±0120,活动组与非活动组、对照组两两相比,差异均有统计学意义(均P<01001);非活动组与对照组相比,差异无统计学意义(P>0105)。所有TAO患者的UR与其CAS具有良好的相关性(r=01859,P<01001)。对活动组患者的治疗前后UR比较,差异有统计学all意义(t=4139,P=01007)。治疗前后CAS比较,差异有统计学意义(Z=-5151,P<0
3、1001),表明治99m疗后评分降低,治疗有效。结论Tc2奥曲肽眼眶显像可帮助临床医师判断TAO炎性反应活动度,为制订治疗方案提供依据,并可用于疗效评价。(中华眼科杂志,2006,42:106821072)【关键词】格雷夫斯病;受体,生长抑素;放射性核素显像;奥曲肽;锝99mClinicalapplicationoforbitalscintigraphywithTc2octreotideinpatientswiththyroidassociatedophthalmopathyDUANLian,LIXian
4、2feng,LUKe2yi,ZHANGCheng2gang,HUGuang,LIUJian2zhong,LISi2jin.DepartmentofNuclearMedicine,theFirstHospitalofShanxiMedicalUniversity,Taiyuan030001,ChinaCorrespondingauthor:LIXian2feng,Email:lixianfeng2lxf@2631net【Abstract】ObjectiveToanalyzethefeasibilityofe
5、stimationofthyroidassociatedophthalmopathy99m(TAO)activitywithorbitalscintigraphyusingTc2octreotide1MethodsTherewere30casesofTAOand11volunteerswithouteyediseaseorthyroiddisease(controlgroup,CG)1Someexaminationswereperformedbeforetreatment1Basedontheclinic
6、alactivityscore(CAS),allTAOpatientsweredividedinto2groups,activegroup(AG)andinactivegroup(IAG)1Orbitscintigraphystudyoforbitwascompleted99mwithin110-115hafterintravenousinjectionof740MBqTc2octreotide1Thebesttransverseslicefordisplayingeyewasselectedtotake
7、semiquantitativeanalysis1Theregionsofinterestofrightorbit(R),leftorbit(L)andoccipital(O)wereselected1Theuptakeratios(UR)werecalculatedin(R+L)/2O1And131then,allactivepatientsacceptedimmunosuppressivetherapywithprednisoneafterItherapy1Sixpatientsperformedoc
8、treotidescantwice1ThestatisticalanalysesincludedANOVA,Spearmanregressionanalysisand99mpairedt2testusingSPSS10101ResultsTc2octreotidebiokineticsshowedarapidbloodclearancethroughurinarysystem1Theorbitappearedasa“colda
