35.饱和氢水减轻大鼠盲肠擦伤致术后粘连

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1、万方数据CHINESEJOURNALOFANATOMYV01．35No．52012解剖学杂志2012年第35卷第5期Hydrogen-richsalineattenuatestheseverityofpostoperativeperitonealadhesioninratcecalabrasionmodelLiuZhenl，JiRuijuan⋯，SunAijunl，HuangHuilon91，SunXuejun2，XiongShaohul△(1．DepartmentofAnatomy，2．DepartmentofDi讲ngMedicine，SecondMi

2、litaryMedicalUniversity，Shanghai200433China)AbstractObjective：Molecularhydrogen，whichreactswiththehydroxylradical，hasbeenconsideredasanovelantioxidantandpossessesprotectioninvariousdiseases．However，theefficacyofhydrogeninpostoperativeperitonealadhesionisun—known．Methods：Intraperit

3、onealadhesionwasinducedinSprague-Dawleyratsbygivingcecalabrasioncombinedwithperi’tonealbuttonandabsolutealcoholovertheabradedcecalserosalsurface，and20ml／kgand30ml／kghydrogen-richsaline(>0．6mmol／L)ornonewasadministered，respectively，v／aintraperitonealinjectiononceadayfor14days．Sever

4、ityofad—hesionpresentedasadhesionscorewasstatisticallyanalyzed．Results：Thehydrogen-richsalinetreatmentgroupshowedsig—nificantlv1essadhesion，whiletherewasnosignificantdifferencebetweenthehydrogenlevelsof20ml／kgand30ml／kgwithinthehydrogen-richsalinetreatedanimals．Conclusion：Hydrogen

5、-richsalinetreatmentsignificantlyattenuatedthese—verityofpostoperativeadhesionformation．Administrationofhydrogen-richsalinehasapotentialuseinclinicasacomple—mentarytherapyforreducingthemorbidityrelatedtopostoperativeadhesions．Keywordshydrogen；postoperativeadhesion；cecalabrasion；ra

6、tPostoperativeintra-abdominaladhesionsarethemostcom-mortcauseofmajorcomplicationofabdominalsurgery．Althoughadhesionsaremostlyasymptomatic，theymaycauseawiderangeofmorbiditiessuchasbowelobstruction．chronicabdominalandpelvicpain，andfemaleinfertility：1一⋯．Inaddition，subsequentlaparotom

7、iesmayhaveanincreasingriskofcomplicationsduetotheadhesions．Themechanismbywhichadhesionform8isstillpoorlyun—derstood．butanincreaseinreactiveoxygenspecies(RoS)pro—ductionduringopenabdominalsurgeryhasbeenreported，i．e．anincreaseofsuperoxideanionsE“，ofxanthineoxidase，anen—zymeinvolvedi

8、nROSformation[“，andofmalondialdeh