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1、1180第四军医大学学报(JFourthMilMedUniv)2005;26(13)http://journal.fmmu.edu.cn·研究原著·文章编号:100022790(2005)1321180205纳米羟基磷灰石修复鼠下颌骨缺损1211董青山,李祖兵,王虎中,郭家平12(广州军区武汉总医院口腔科,湖北武汉430070,武汉大学口腔医学院口腔颌面外科,湖北武汉430079)Anexperimentalstudyonreconstruc2newlydevelopedcartilagematrixoforigin
2、alcalluses,mono2nuclearmacrophage,multinuclearmacrophageandintersti2tionofratmandibularbonedefectstialcellsofthegranulartissue.Ateachexperimentphase,withnano2hydroxyapatitenano2HAgroupshowedahigherTGF2β1expressionthan121thatinordinaryHAgroupandtheTGFDONGQing2Sh
3、an,LIZu2Bing,WANGHu2Zhong,GUOJia22β1expressionof1bothnano2HAgroupandHAgroupwashigherthanthatinPing1controlgroup.CONCLUSION:HAisanidealmaterialforDepartmentofStomatology,WuhanGeneralHospitalofGuang2zhouCommand,Wuhan430070,China,2DepartmentofMaxillo2thereconstruc
4、tionofmandibularbonedefects.Nano2HAisfacialSurgery,CollegeofStomatatology,WuhanUniversity,Wu2superiortoordinaryHAinitsbiocompatibilityandosteogen2han430079,Chinaesis.【Keywords】mandibulardefect;nano2hydroxyapatite;im2【Abstract】AIM:Tocomparetheosteogenicabilitybe
5、2munohistochemistrytweenhydroxyapatite(HA)andnano2HAinrepairingman2dibularbonedefectandtoinvestigatetheadvantageofu2【摘要】目的:比较纳米羟基磷灰石(nano2HA)和HA修复singnano2HA.METHODS:Seventy2fiveadultSDrats下颌骨缺损的成骨能力,探讨nano2HA材料的优越性.方法:wererandomlyassignedtofiveexperimentalgrou
6、ps,with选择SD大鼠75只,随机分1,2,3,4,8wk共5个时间段,每时间段15只,对大鼠下颌骨下缘作一4.0mm×2.5mm的15ineachgroup.Aftera4.0mm×2.5mmrectangular矩形骨缺损区,分别用大小为1.5mm×2.5mm×4.0mm的bonedefectwasproducedatthebottomlineofthemandib2nano2HA材料、HA材料修复缺损区,另设一组空白对照组.ular,4.0mm×2.5mm×1.5mmnano2HAorHAwasre2分期取
7、出缺损区骨组织,进行肉眼观察、光镜和免疫组化spectivelyusedtorepairthebonedefectarea.Acontrol(TGF2β1)检测,最后对免疫组化检测结果量化并进行统计学groupwassetupsimultaneously.Theanimalswerekilled分析.结果:大体观察见nano2HA修复组缺损区骨痂出现早at1,2,3,4and8weeksrespectivelyaftertheoperation而厚.光镜见nano2HA组骨细胞增生活跃,1wk有新生骨形andthes
8、pecimenswereobtainedformacromorphological成,炎症反应轻;HA组骨修复细胞较活跃,炎症反应较明显,observation,lightmicroscopic(LM)andimmunohisto2且术后3wk才逐渐消退.免疫组化结果显示:在原始骨痂中chemical(TGF2β1)examination.Th
