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1、低温射频消融术治疗阻塞性睡眠呼吸暂停低通气综合征【摘要】探讨低温射频消融术(temperaturecontrolledradiofrequencyablation,TCRF)治疗阻塞性睡眠呼吸暂停低通气综合征(obstructivesleepapneahypopneasyndrome,OSAHS)的疗效和手术前后生活质量的变化。方法：对50例OSAHS患者行TCRF治疗,比较治疗前后呼吸暂停低通气指数(apneahypopneaindex,AHT)>最低血氧饱和度(lowestarterialoxygeonsaturat
2、ion,LSa02)>Epworth嗜睡评分(EpworthSIeepinessScale,ESS)和Calgary生活质量指数(CalgarySleepApneaQualityofLifeIndex,SAQLI),从主、客观方面对TCRF治疗OSAHS进行疗效评价。结果：术后6个月复查多导睡眠监测(polysomnography,PSG),50例患者中总有效43例，其中治愈19例,显效18例,有效6例,无效7例，总有效率86.0%。手术前后AHT平均值分别为45.20+20.50和26.50+30.15,LSa02平均
3、值分别为0.70+0.24和0・83+0.10。Epworth嗜睡程度评分由术前9.4+5.2下降至术后4.0+3.3,SAQLI总分从术前3.9+1.0提高到术后4.7+1.1,差异均有统计学意义(P值均V0.05)o结论：TCRF是治疗OSAHS的有效方法，可提高OSAHS患者的生活质量。【关键词】睡眠呼吸暂停低通气综合征阻塞性等离子射频消融生活质量[ABSTRACT]Objective:Todeterminetheefficacyoftemperature-controlledradiofrequencyablat
4、ion(TCFR)forobstructivesleepapneahypopneasyndrome(OSAHS)inadult・Methods:SomeobjectiveandsubjectiveindexesoffiftypatientswithOSAHSweredeterminedbeforeandafterTCRFtreatment.Afu11nightpolysomnographyexaminationwasperformedonal1patients・TheEpworthsleepinessscale(ESS)
5、andtheCalgarysleepapneaqualityoflifeindex(SAQLI)wereassessedbeforeandsixmonthsafteroperation.Results:Ofthem,19caseswerecured,18casesweresignificantlyimproved,16caseswereimproved,and7caseswerenotimproved・Themeanapneahypopneaindex(AHI)decreasedfrom(45.2+20.5)/hto(2
6、6.5+30.2)/handthemeanlowestarterialoxygensaturation(LSa02)increasedfrom(0.7+0.1)to(0.8+0.1)・TheESSdecreasedfrom(9.4+5.2)to(4.0+3.3)andtheSAQLIincreasedfrom(3.8+1.0)to(4.8+1.1).Al1theabovedifferencesweresignificant(P<0.05).Conclusion:TCFRisaneffectivetreatmentforO
7、SAHSandcanimprovethehealthrelatedqualityoflife.obstructive;[KEYWORDS]Sleepapneahypopneasyndrome,Plasmaradiofrequency；Ablation；Healthrelatedqualityoflife低温射频消融术(temperaturecontrolledradiofrequencyablation,TCRF)是近几年开展的治疗阻塞性睡眠呼吸暂停低通气综合征(obstructivesleepapneahypopnea
8、syndrome,OSAHS)的——种微创技术，通过缩小下鼻甲、软腭、悬雍垂、扁桃体和舌根等组织体积，解除上呼吸道阻塞以治疗OSAHS,术中可以同时对多个狭窄和阻塞平面进行处理。我院耳鼻咽喉科2003年8月至2006年5月采用等离子射频手术系统(ENTecCoblatorTM)对50例0SAHS患者进行治疗,术后从主
