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《前列腺腺癌患者年龄与血清PSA相关性初步分析-论文.pdf》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、堡鳖垦生堕月中杂志2014年6月第6卷第3期JContempUrolReprodOncol,June2014,Vol6,N0.3·临床研究前列腺腺癌患者年龄与血清PSA相关性初步分析王功伟沈丹华do~:10.3870/j.issn.1674—4624.2014.03.006【摘要】目的探讨前列腺腺癌患者年龄与血清PSA的关系。方法比较前列腺腺癌患者不同年龄组别血清TPSA、FPSA及F/TPsA比值均值,比较不同血清TPSA、FPSA以及F/TPsA比值组别年龄均值,研究患者年龄与血清TPSA、FPSA及F/TPSA比值相关性。结果<6o岁、60~69岁、70~79岁、≥8O岁组血清TP
2、sA均值分别为(45.79i-33.35)、(59.524-35.88)、(61.95±42.36)和(36.35土26.88)ng/ml,血清FPSA均值分别为(8.17±7.61)、(13.50±9.81)、(11.25土10.40)和(3.92±2.28)ng/ml,F/TPSA比值均值分别为0.15±0.07、0.20±0.16、0.21土0.16和0.17±0.08,组间比较差异有统计学意义(P<0.05)。相关性分析前列腺腺癌患者年龄与血清TPSA(R一0.683,P一0.000)、血清FPSA(R一0.577,P一0.000)和F/TPSA比值(R。一0.656,P:0.o
3、oo)具有显著相关性。结论前列腺腺癌患者年龄与血清TPSA、FPSA和F/TPsA比值呈曲线相关性,三者先随着年龄增加呈现逐渐上升趋势,而后随着年龄增加呈现逐渐下降趋势。【关键词】前列腺肿瘤;前列腺特异抗原;年龄;相关性RelationshipoftheageandserunlPSAinpatientswithprostateadenocarcinoma:apreliminaryanalysisW_ANGGong—wei,SHENDan—hua.DepartmentofPathology,PeoplesHospital,Peking—versity,Beijing】00044,China
4、Corrs0gauthor:SHENDan—hua,E-mail:shenpath59@j63.corn[Abstract]ObjectiveToexploretherelationshipoftheageandserumPSAinpatientswithprostateadenoeareinoma.MethodsWestudiedthemeanlevelofserumtotalPSA(TPSA),freePSA(FPSA)andF/TPSAratiosofdifferentage—groups,andcomparedwithdifferentmeanlevelofserumTPSA,F
5、PSA,andF/TPSAratios,andstudiedtheralationshipoftheageandserumTPSA,FPSAandF/TPSAratio.ResultsMcanserumTPSAwere(45.79±33.35)ng/mlin<60year,(59.52±35.88)ng/mlin60~69year,(61.95±42.36)ng/mlin7O~79year,and(36.35±26.88)ng/mlin≥80year.MeanserumFPSAwere(8.17±7.61)ng/ml,(13.50±9.81)ng/ml,(11.25±10.40)ng/m
6、l,and(3.92±2.28)ng/mlindifferentage—groups,respectively.Meanser—umF/TPSAratiowere0.15±0.07,0.20士0.16,0.21±0.16,and0.174-0.08indifferentage—groups,respectively.Thereweresignificantlystatisticaldifferenceindifferentgroups(P<0.05).Theageofpatientswithprostateadenocarcinomahassignificantlyrelatedtose
7、rumTPSA(R。一0.683,P一0.000),serumFPSA(R。一0.577,P一0.000)andF/TPSAratios(R。一0.656,P一0.000).ConclusionsTheageofpatientwithprostateadenocarcinomahascurvilinearcorrelationtoserumTPSA,serumFPSAandF/TPSAratios.Thethreeindexwere
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