吡格列酮对2型糖尿病患者血清TNF-α生物学活性及脂联素水平的影响-论文.pdf

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1、中国现代医药杂志2013年12月第15卷第12期MMJC，Dec2013，Vol15，No．12·59·吡格列酮对2型糖尿病患者血清TNF—o【生物学活性及脂联素水平的影响苏佩合姜艳何岚贺明【摘要】目的研究吡格列酮对2型糖尿病患者血清脂联素、TNF—OL生物学活性的影响，探讨2型糖尿病与炎症、脂肪因子的关系。方法选取84例2型糖尿病患者为病例组，102例健康体检者为对照组，病例组患者接受吡格列酮治疗3个月，用放射免疫药盒测定血清脂联素，MTY比色法检测TNF一0【的生物学活性。结果病例组患者血清脂联素低于对照组(P<0．05)，TNF—

2、Or．的生物学活性高于对照组(尸0．05)，血清脂联素与BMI及Homa—IR呈负相关，TNF—Of．的生物学活性与BMI及Homa—IR呈正相关。结论2型糖尿病是慢性炎性疾病，炎症状态与肥胖及血糖控制有关，吡格列酮通过增加血清脂联素水平改善胰岛素抵抗。【关键词】2型糖尿病炎症TNF—脂联素吡格列酮EfectofpioglitazoneonbiologicalactivityofserumTNF-o~andadipo

3、nectinlevelinT2DMpatientsSuPeihe，Yan，HeLan，eto1．DepartmentofEndocrinology，Xi"anAerospaceGeneralHospital，Xi"an710100【Abstract】ObjectiveTostudytheeffectofpioglitazoneonserumadiponectinlevelandbiologicalactivityofserumTNF—inT2DMpatients．ToinvestigatecorrelationsbetweenT2DMa

4、ndinflammation．adipokines．Methods102healthyvol-unteersservedascontrolsubjects，84diagnosedtype2diabeticpatientshadbeentreatedwithpioglitazonefor3months．ThebiologicalactivityofserumTNF—withM1TcolorimetricmethodandadiponectinlevelwithRIAhadbeenmeasuredbeforeandafterpioglita

5、zone，respectively．CorrelationanalysiswasconductedbetweenthesedataandBMI，Homa-IR．ResultsDecreasedadiponectinwasfoundintype2diabetespatientscomparedtothehealthysubjects(P<0．05)，T2DMgroupshowedthehigherofbiologicalactivityofserumTNF一0【thanthatofhealthysubjects(P<0．05)．Treat

6、mentwithpioglitazoneelevatedadiponectin(PO．05)．Correla—tionanalysisindicatedsignificantnegativecorrelationsofserumadiponectinlevelwithBMIandHoma—IR．Therewassignificantpositivec

7、orelationbetweenbiologicalactivityofTlNF一0【andBMI．Homa—IR．ConclusionT2DMisalow—gradechronicin．flammatorydisease，obesityandqualityofglucosecontrolmaybepositivelyassociatedwiththechronicinflammation．Pioglita．zonewhichincreasedadiponectinexpressionandsecretioncaneffectively

8、improveinsulinresistanceintype2diabetes．【Keywords】Type2diabetesInflammationTNF一0lAdiponectinPioglitazon