阿立哌唑与利培酮治疗阿尔兹海默病性痴呆精神症状的临床对照-论文.pdf

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1、昆明医科大学学报2013。(12)：114—116CN53—1221／RJournalofKunmingMedicalUniversity阿立哌唑与利培酮治疗阿尔兹海默病性痴呆精神症状的临床对照胡东辉”，王阿静(1)汉中市精神病医院，陕西汉中723003；2)西安市户县医院，陕西西安710300)[摘要]目的探讨阿立哌唑与利培酮治疗阿尔兹海默病性痴呆精神症状的临床疗效．方法选择阿尔兹海默病性痴呆合并精神症状患者64例，分为利培酮+多奈哌齐组(A组)和阿立哌唑+多奈哌齐组(B组)，分别于治疗前及治疗后4、8周采用BEHAV—AD量表进行评定患者

2、病理行为，并采用副反应量表(TESS)评定药物不良反应．结果A组治疗后4周BEHAV—AD评分较治疗前差异无统计学意义(P>O．05)，治疗8周后显著下降(P<0．05)．B组治疗4周及8周后均出现显著下降(PO．05)．2组治疗后4周TESS评分差异无统计学意义(P>0．05)，治疗8周后B组TESS评分显著低于A组(P<0．05)．结论阿立哌唑

3、+多奈哌齐可有效缓解该类患者精神症状并有较低的副反应发生，治疗阿尔兹海默病性痴呆合并精神症状效果更好．[关键词]阿立哌唑；利培酮；阿尔兹海默病；精神症状[中图分类号]R749．16[文献标识码]A[文章编号]2095-610X(2013)12—0114—03AComparativeStudyofAripiprazoleandRisperidoneintheTreatmentofAlzheimer’SDiseaseDementiaCombinedPsychiatricSymptomsHUDong-hui，WANGA—jing(Psychiatr

4、icHospitalofHangzhong，HangzhongShaanxi723003；2)HuxianCountyHospital，Xi’帆ShaanxiShaanxi710300，China)[Abstract]ObjectiveToinvestigateandcomparethetherapeuticeffectofaripiprazoleandrisperidoneinthetreatmentofpsychiatricsymptomsinAlzheimer’Sdiseasedementia．Methods64patientsofAl

5、zheimer’Sdiseasedementiawithpsychiatricsymptoms，weredividedintorisperidonedonepezilgroup(A)andaripiprazoledonepezilgroup(B)．Beforeand4，8weeksaftertreatment，theBEHAV-ADscalewasusedtoassessthepathologicalbehaviorandthesideeffectsscale(TESS)wasusedtoassessadversedrugreactions．

6、ResultsAgroupat4weeksaftertreatmentBEHAV—ADscoreshowednosignificantdifferencewithbeforetreatment(P>0．05)，8weeksaftertreatmentdecreasedsignificantly(P<0．05)．GroupB4weeksand8weeksaftertreatmentBEHAV—ADscorewassignificantlydecreased(P<0．05)．BEHAV—ADscoreinGroupB4weeksand8weeks

7、aftertreatmentwassignificantlylowerthangroupA(P<0．05)．Thescoresinbehavioraldisorders，depression，anxietyinGroupBweresignificantlylowerthangroupA(P<0．05)，thescoresinparanoia，hallucinations，aggressivebehavior，deliriumshowednosignificantdifferencebetweentwogroups(P>0．05)．4weeks

8、aftertreatment，thetwogroupshadnosignificantdifferenceinTESSscore(P>O．05)，8weeksaft