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《可溶性转铁蛋白受体检测对非成年人缺铁性贫血的诊断价值.pdf》由会员上传分享,免费在线阅读,更多相关内容在应用文档-天天文库。
1、国际检验医学杂志2014年7月第35卷第14期IntJLabMeal,July2014,Vo1.35,No.14·1885··临床检验研究论著·可溶性转铁蛋白受体检测对非成年人缺铁性贫血的诊断价值蒋玉莲,莫丽亚,张聪,邱碧波(湖南省儿童医院检验科,湖南长沙410007)摘要:目的探讨可溶性转铁蛋白受体(sTfR)对非成年人缺铁性贫血(IDA)的诊断价值及其与慢性病贫血(ACD)的鉴别诊断价值。方法IDA组26例,男12例,女14例,年龄1月至15.5岁;ACD组33例,男17例,女16例,年龄2月至14.0岁;对照组3O例,男15例,女15例
2、,年龄1月至15.5岁。sTfR、铁蛋白(SF)检测方法为免疫比浊法,血清铁(SI)为亚铁嗪比色法。结果各组患儿的性别比例、年龄无显著性差异;ACD组的SI均值介于IDA组和对照组之间;IDA组的SF显著低于ACD组(P<0.001)和对照组(P<0.001),而sTfR显著高于ACD组(P<0.001)和对照组(P<0.001)。sTfR鉴别诊断IDA和AcD的截值为3.56mg/L,其敏感性、特异性、阴性预测值、阳性预测值、准确性分别为95.12、93.92、94.11、97.53、95.5O。结论sTfR对IDA具有较高的敏感性及特异性
3、,有助于诊断IDA及鉴别诊断ACD。关键词:非成年人;受体;转铁蛋白;诊断;缺铁性贫血;慢性病贫血D0I:10.3969/j.issn.1673—413O.2O14.14.029文献标识码:A文章编号:1673—4130(2O14)14-1885—02Diagnosticvalueofsolubletransferrinreceptordetectioninnon-adultiondeficiencyanemiaJiangYulian,MoLiya,ZhangCong,QiuBibo(DepatrmentofClinicalLaborator
4、y,HunanProvincialChildrensHospital,Changsha,Hunan410007,China)Abstract:ObjectiveToinvestigatethediagnosticvalueofthesolubletransferrinreceptor(sTfR)innon—adultirondeficiencyanemia(IDA)anditsdifferentialdiagnosticvaluebetweenIDAandanemiaofchronicdisease(ACD).Methods26casesin
5、theIDAgroupinvolved12malesand14females,aged1monthto15.5years;33easesintheACDgroupinvolved17malesand16females,aged2monthsto14.0years;30casesinthenormalcontrolgroupinvolved15malesand15females,aged1monthto15.5years.SerumsTfRandferritin(SF)weredetectedbytheimmunonehelomitery,se
6、rumiron(SI)wasdetectedbyFerrousOxazineeolori—metricmethod.ResultsThegenderandagehadnostatisticallysignificantdifferenceamong3groups;theSImeanvalueintheACDgrouplocatedbetweentheIDAgroupsandthenormalcontrolgroups;theSFmeanvalueoftheIDAgroupwassignificantlylowerthanthatofACDgr
7、oup(P<0.001)andthatofcontrolgroup(P%0.001),whilethesTfRmeanvalueofIDAgroupwassignificantlyhigherthanthatoftheACDgroup(P8、epredictivevalue,posi—tivepredictivevalueandaccuracywere95.12,93.92,94.11,97.53and
8、epredictivevalue,posi—tivepredictivevalueandaccuracywere95.12,93.92,94.11,97.53and
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