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《同型半胱氨酸和C反应蛋白与2型糖尿病大血管病变的关系研究.pdf》由会员上传分享,免费在线阅读,更多相关内容在应用文档-天天文库。
1、852JBengbuMedColl,July2014,Vo1.39,No.7[文章编号]1000-2200(2014)07-0852-03·临床医学·同型半胱氨酸和C反应蛋白与2型糖尿病大血管病变的关系研究孙卫华,张晓梅,李晓丽,时照明。裴晓艳。吴道爱[摘要]目的:探讨血浆同型半胱氨酸(Hcy)和C反应蛋白(CRP)与2型糖尿病大血管病变的关系。方法:免疫比浊法检测正常对照组(30名)、单纯糖尿病组(32例)及糖尿病大血管病变组(31例)血浆Hcy和CRP水平,观察其水平变化与糖尿病大血管病变的关系。结果:糖尿病大m管病变组和单纯糖尿病组血浆Hcy和CRP均明显
2、高于正常对照组(P<0.01),单纯糖尿病组Hcy和CRP均显著低于糖尿病大血管病变组(P<0.01);logistic回归分析显示收缩压、舒张压、糖化血红蛋白、三酰甘油、总胆固醇、高密度脂蛋白、Hcy和CRP均与动脉粥样硬化的发生相关。结论:2型糖尿病大血管病变患者血浆Hcy和CRP水平明显升高,消除动脉粥样硬化的危险因素如减轻体质量、控制血糖、纠正脂代谢紊乱、增强胰岛素敏感性、降血压等综合治疗可预防和延缓动脉粥样硬化的发生。[关键词]糖尿病性血管病;同型半胱氨酸;C反应蛋白;大血管病变[中国图书资料分类法分类号]R587.2【文献标志码]ATherelati
3、onshipbetweenthelevelsofhomocysteineandC-reactiveproteinandmacroangiopathyintype2diabetesmellitusSUNWei—hua,ZHANGXiao—mei,LIXiao—li,SHIZhao—ming,PEIXiao—yan,WUDao—ai(DepartmengtofEndocrinology,TheFirstAffiliatedHospitalofBengbuMedicalCollege,BengbuAnhui233004,China)[Abstract]Objectiv
4、e:Toinvestigatetherelationshipbetweenthelevelsofhomocysteine(Hcy)andC—reactiveprotein(CRP)andmacroangiopathyintype2diabetesmellitus.Methods:ThelevelsofplasmaHcyandCRPincontrolgroup(30cases),simplediabetesmellitusgroup(32cases)anddiabeticmacroangiopathygroup(31cases)weredetectedusingi
5、mmunoturbidimetry.TherelationshipbetweenthelevelsofHcyandCRPanddiabeticmacroangiopathywasanalyzed.Results:ThelevelsofplasmaHcyandCRPinsimplediabetesmellitusanddiabeticmacroangiopathygroupweresignificantlyhigherthanthoseincontrolgroup(P<0.01),thelevelsofplasmaHeyandCRPinsimplediabetes
6、meliitusgroupweresignificantlylowerthanthoseinanddiabeticmacroangiopathygroup(P<0.01).Logisticregressionanalysisshowedthatthelevelsofsystolicbloodpressure,diastolicbloodpressure,HbA1C,triglyceride,totalcholesterol,hi.ghdensitylipoprotein,HcyandCRPwerecorrelatedtoartherosclerosis.Conc
7、lusions:ThelevelsofplasmaHcyandCRPintype2diabeticpatientswithmacroangiopathyincreasedsignificantly.Thetreatmentwithlosingbodymass,controllingbloodglucose,correctinglipidmetabolismdisorder,increasinginsulinsensitivityreducingbloodpressurecanpreventanddelaytheoccurrenceofartheroscleros
8、is.[Keywords
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