骨瓜提取物注射液治疗膝骨性关节炎疗效观察.pdf

《骨瓜提取物注射液治疗膝骨性关节炎疗效观察.pdf》由会员上传分享，免费在线阅读，更多相关内容在应用文档-天天文库。

1、848网JMedTheor&PracVo1．27，No．7，Apr20142014年第27卷第7期麓掌瑗论鞲蔽艘骨瓜提取物注射液治疗膝骨性关节炎疗效观察郭伟李娴贺新宁1湖南省株洲市中医伤科医院骨科412000；2株洲市中心医院田心院区摘要目的：观察骨瓜提取物注射液治疗膝骨性关节炎的临床疗效及其潜在治疗机制。方法：将6O例患者随机分为2组，试验组30例用骨瓜提取物注射液50rag加入250mi0．9氯化钠注射液中静脉滴注，1次／d，同时口服尼美舒利胶囊，lOOmg／次，2次／dl对照组30例口服氨基葡萄糖胶囊，480mg／次，3次／d，同时口服尼美舒利胶囊，100mg／

2、次，2次／d。连续治疗30d后评定疗效，并检测治疗前、后膝关节液中自细胞介素一I(IL-1)的水平变化。期间停服其他抗炎镇痛药、肾上腺糖皮质激素和其他缓解症状的治疗OA慢作用的药物。结果：试验组总有效率优于对照组，且存在统计学差异(．)c=5．455；P=O．042<0．05)；试验组和对照组患者膝关节液IL_1值与治疗前比较均明显下降，且有统计学意义(丁=3．74，4．01；P均

3、关键词骨瓜提取物注射液膝骨性关节炎Il、中图分类号：R684．3文献标识码：A文章编号：1O0l一7585(2O14)O7一O848一O2EfficacyofCervusandCucumisPolypeptideforInjectiononOsteoarthritisoftheKneeGUOWei*，LIFAan，HEFAnning．*TraditionalChineseMedicine丁r盘umatologyHospitalofZhuzhoua砂，H’nanProvi，口412000ABs1ACTObjective：Toobservetheclinica1effic

4、acyandpotentialtherapeuticmechanismofCervusandCucumisPoly-peptideforInjectionontheOsteoarthritisofkne皂Methods：60patientswererandomlydividedinto2groups．CervusandCucumisPolypeptideforInjection50mgthataddedin250rrdof0．9％sodiumchlorideinjectionwasusedintreat—mentgroup，1timeaday；glucosaminec

5、apsules480mgeachtime，wastakenincontrolgroup，3timesaday．AtthesametimeNimesulideCapsuleslOOmgeachtime，wasusedinbouthtreatmentgroupandcontrolgroup，2timesaday．30dayslater，curativeeffecttobeevaluated，andIL一1levelweredetectedinkneeiointfluidinterleukininordertoob—servethechanges．Duringthetime

6、otherant~inflammatoryanalgesic，adrenalglucoeorticoidsandotherrelievesyrup-tomsdrugsforthetreatmentofOAslowaction．werebanned．Results：Thetotaleffectivenessoftreatmentgroupisbet—terthanthecontrolgroup，andthereisastatisticaldifference(：(z；5．455；P=0．042<0．05)；theIL_1valueintreat—mentgroupand

7、controlgroupweresignificantlydecreasedthanbeforetreatment(丁=3．74，4．01；P<0．05)．Thedifferenceofn1betweenthetwogroupsaftertreatment，therearesignificantdifference(T=5．52，P<0．05)．Con—clusion：CervusandCucumisPolypeptideforInjectionhasagoodcurativeeffectiononkneeosteoarthritis；anditca