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《高血压病合并抑郁症患者血清甲状腺激素水平的研究.pdf》由会员上传分享,免费在线阅读,更多相关内容在应用文档-天天文库。
1、·68·生!旦筮!鲞箜塑ekinJClinicians(ElectronicEdition)。July1。2013.Vo1.7.No.13·临床论著·高血压病合并抑郁症患者血清甲状腺激素水平的研究张洁赵兴胜景兰史萌萌【摘要】目的探讨高血压病合并抑郁症患者血清甲状腺激素水平的变化。方法采用化学发光法分别测定高血压病合并抑郁症组(n=50)、高血压病组(n=50)、抑郁症组(n=50)、健康对照组(n=50)的血清甲状腺激素FT3、El'4、TSH水平并进行比较。结果高血压病合并抑郁症组的FT3浓度明显低于高
2、血压病组、抑郁症组和健康对照组(P=0.036,P=0.041,P=0.000)。四组中低rI3综合征的发生率分别为:35.0%、22.O%、12.0%、4.0%,且差异有显著性(x:10.821,P=0.010)。高血压病合并抑郁症组的血清FT3浓度与高血压病分级、汉密顿(HAMD)量表总分均呈负相关(P=0.000,P=0.013)。控制HAMD量表总分时,其F13浓度与高血压病分级的偏相关系数为一0.584,P=0.000。控制高血压病分级时,其FT3浓度与HAMD量表总分的偏相关系数为一0.365
3、,P=0.044。结论高血压病合并抑郁症患者的血清兀.3浓度明显下降,更易发生低1r3综合征,且其FT3浓度与高血压病分级、HAMD量表总分之间均存在负相关关系,F3水平可以作为判断高血压病合并抑郁症患者病情严重程度的指标之一,对判断预后及指导治疗具有重要意义。【关键词l抑郁症;高血压;甲状腺激素类StudyofserbiathyroidhormoneinhypertensionpatientsthdepressionZHANGJie,ZHAOXing-sheng,】lNGLan.SHIMeng—meng
4、.DepartmentofEndocrinology.TheFirstHospitalinHohhot.HohhotO10000。ChinaCorrespondingauthor:ZHA0一sheng,Entail:ZXSl121@yahoo.con.eR【Abstract】0bjectiveTostudythealterationofserumthyroidhormoneF13,FT4,TSHinhypertensionpatientswithdepression.MethodsTheserumF3,F
5、T4,TSHlevelsweremeasuredwithchemilhypertensionpatientswithdepressiongroup(=50),hypertensiongroup(n=50),patientswithdepression(n=50),healthycontrolgroup(n=50)andthencompared.ResultsTheserumFT3concentrationsofhypertensionpatientswithdepressiongroupweresigni
6、ficandylowerthantheotherthreegroups(P=0.036,P=0.041,尸=0.000).ItsserumFF4concentrationsweresignificantlylowerthanthehealthycontrolgroup(P:0.028).TheincidencerateoflowrI3syndromeinfourgroupsrespectivelywere35.0%,22.O%,12.0%,4.0%anddifferencebetweenthemwassi
7、gnificant(x=10.821,P=0.010).TherewasanegativecorrelationbetweentheserumFr3concentrationsofhypertensionwithdepressiongroupandhypertensiongrade,Hamiltondepressionscale(HAMD)totalscore(P=0.000,P=0.013).ControltheHAMDtotalscore,thepartialcorrelationcoefficien
8、tofthemconcentrationsandhypertensiongradewas一0.584,P=0.000.Controlthehypertensiongrade,thepartialcorrelationcoeficientoftheFT3concentrationsandtheHAMDtotalscorewas一0.365.P=0.044.ConclusionTheserumrI3concentrationsof
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