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时间:2020-04-19
《甘露聚糖肽联合顺铂治疗恶性胸水的临床疗效观察.pdf》由会员上传分享,免费在线阅读,更多相关内容在应用文档-天天文库。
1、·临床探讨·2013年9月第51卷第27期甘露聚糖肽联合顺铂治疗恶性胸水的I临床疗效观察刘传枝南京市溧水区人民医院,江苏南京210000【摘要】目的探讨甘露聚糖肽联合顺铂治疗恶性胸水的临床疗效。方法收集2011年12月~2012年12月在我院就诊的恶性胸水70例,随机分为观察组和对照组各35例。两组均行常规胸腔穿刺闭式引流术,观察组同时加甘露聚糖肽联合顺铂治疗,对照组同时加顺铂治疗,比较两组的疗效及两组生活质量改善情况。结果观察组治疗后的总有效率达82.9%,其疗效明显优于对照组,差异具有显著性(X2=4.738,P2、优于对照组,差异具有显著性(u=3.65,P3、etreatmentofmalignantpleuralefusionobser—vationLlUChuanzhNanjingCityLishuiDistrictPeople’SHospital,Nanjing210000,China[Abstract]0bjectiveToinvestigatetheeffectofMannatideandcisplatintreatmentofmalignantpleuraleffusion.MethodsFromDecember2011toDecember2012inourhospital,70casesofmaligna4、ntpleuraleffusionwererandomlydividedintoobservationgroupandcontrolgroup,35patientsinbothgroupsunderwentroutinethoracentesiswithcloseddrainage,whiletheobservationgroupplusMannatidecisplatin,whilethecontrolgrouppluscisplatintreatment,theefficacyandqualityoflifeimprovementwerecomparedbet5、weentwogroups.ResultsAftertreatment,thetotaleffectiverateoftheobservationgroupwas82.9%.anditsefficacywassignificantlybetterthanthecontrolgroup,thediferencewassignificant(X2=4.738,P<0.05).Aftertreatment,thequalityoflifetoimprovethesitua-tionoftheobservationgroupwassignificantlybetterth6、anthecontrolgroup,thedifferencewassignificant(“=3.65,P7、blepatients,threecasesafterinjection,fever,chestpain,nausea,aftersymptomaticremissionaftertreatment.Thetwogroupswerenotsecondarychestinfection,liverandkidneydysfune—tion.ConclusionMannatideandcisplatinintreatmentofmalignantpleuraleffusionhavegoodeffect,cansignificant—lyimprovethepatie8、nt'sq
2、优于对照组,差异具有显著性(u=3.65,P3、etreatmentofmalignantpleuralefusionobser—vationLlUChuanzhNanjingCityLishuiDistrictPeople’SHospital,Nanjing210000,China[Abstract]0bjectiveToinvestigatetheeffectofMannatideandcisplatintreatmentofmalignantpleuraleffusion.MethodsFromDecember2011toDecember2012inourhospital,70casesofmaligna4、ntpleuraleffusionwererandomlydividedintoobservationgroupandcontrolgroup,35patientsinbothgroupsunderwentroutinethoracentesiswithcloseddrainage,whiletheobservationgroupplusMannatidecisplatin,whilethecontrolgrouppluscisplatintreatment,theefficacyandqualityoflifeimprovementwerecomparedbet5、weentwogroups.ResultsAftertreatment,thetotaleffectiverateoftheobservationgroupwas82.9%.anditsefficacywassignificantlybetterthanthecontrolgroup,thediferencewassignificant(X2=4.738,P<0.05).Aftertreatment,thequalityoflifetoimprovethesitua-tionoftheobservationgroupwassignificantlybetterth6、anthecontrolgroup,thedifferencewassignificant(“=3.65,P7、blepatients,threecasesafterinjection,fever,chestpain,nausea,aftersymptomaticremissionaftertreatment.Thetwogroupswerenotsecondarychestinfection,liverandkidneydysfune—tion.ConclusionMannatideandcisplatinintreatmentofmalignantpleuraleffusionhavegoodeffect,cansignificant—lyimprovethepatie8、nt'sq
3、etreatmentofmalignantpleuralefusionobser—vationLlUChuanzhNanjingCityLishuiDistrictPeople’SHospital,Nanjing210000,China[Abstract]0bjectiveToinvestigatetheeffectofMannatideandcisplatintreatmentofmalignantpleuraleffusion.MethodsFromDecember2011toDecember2012inourhospital,70casesofmaligna
4、ntpleuraleffusionwererandomlydividedintoobservationgroupandcontrolgroup,35patientsinbothgroupsunderwentroutinethoracentesiswithcloseddrainage,whiletheobservationgroupplusMannatidecisplatin,whilethecontrolgrouppluscisplatintreatment,theefficacyandqualityoflifeimprovementwerecomparedbet
5、weentwogroups.ResultsAftertreatment,thetotaleffectiverateoftheobservationgroupwas82.9%.anditsefficacywassignificantlybetterthanthecontrolgroup,thediferencewassignificant(X2=4.738,P<0.05).Aftertreatment,thequalityoflifetoimprovethesitua-tionoftheobservationgroupwassignificantlybetterth
6、anthecontrolgroup,thedifferencewassignificant(“=3.65,P7、blepatients,threecasesafterinjection,fever,chestpain,nausea,aftersymptomaticremissionaftertreatment.Thetwogroupswerenotsecondarychestinfection,liverandkidneydysfune—tion.ConclusionMannatideandcisplatinintreatmentofmalignantpleuraleffusionhavegoodeffect,cansignificant—lyimprovethepatie8、nt'sq
7、blepatients,threecasesafterinjection,fever,chestpain,nausea,aftersymptomaticremissionaftertreatment.Thetwogroupswerenotsecondarychestinfection,liverandkidneydysfune—tion.ConclusionMannatideandcisplatinintreatmentofmalignantpleuraleffusionhavegoodeffect,cansignificant—lyimprovethepatie
8、nt'sq
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